Recent Evolutionary History of Tigers Highlights Contrasting Roles of Genetic Drift and Selection

被引：47

作者：

Armstrong, Ellie E. ^{[1
]}

Khan, Anubhab ^{[2
]}

Taylor, Ryan W. ^{[1
,3
]}

Gouy, Alexandre ^{[4
,5
]}

Greenbaum, Gili ^{[1
,6
]}

Thiery, Alexandre ^{[4
,5
]}

Kang, Jonathan T. ^{[7
]}

Redondo, Sergio A. ^{[1
]}

Prost, Stefan ^{[1
]}

Barsh, Gregory ^{[8
,9
]}

Kaelin, Christopher ^{[9
]}

Phalke, Sameer ^{[10
]}

Chugani, Anup ^{[10
]}

Gilbert, Martin ^{[11
,12
]}

Miquelle, Dale ^{[11
]}

Zachariah, Arun ^{[13
]}

Borthakur, Udayan ^{[14
]}

Reddy, Anuradha ^{[15
]}

Louis, Edward ^{[16
]}

Ryder, Oliver A. ^{[17
]}

Jhala, Yadvendradev, V ^{[18
]}

Petrov, Dmitri ^{[1
]}

Excoffier, Laurent ^{[4
,5
]}

Hadly, Elizabeth ^{[1
]}

Ramakrishnan, Uma ^{[2
]}

机构：

[1] Stanford Univ, Dept Biol, Stanford, CA 94305 USA

[2] TIFR, Natl Ctr Biol Sci, Bangalore, Karnataka, India

[3] End2End Genom LLC, Davis, CA USA

[4] Univ Bern, Inst Ecol & Evolut, Bern, Switzerland

[5] Swiss Inst Bioinformat, Lausanne, Switzerland

[6] Hebrew Univ Jerusalem, Dept Ecol Evolut & Behav, Jerusalem, Israel

[7] ASTAR, Genome Inst Singapore, Singapore, Singapore

[8] Hudsonalpha Inst, Huntsville, AL USA

[9] Stanford Univ, Dept Genet, Stanford, CA 94305 USA

[10] Magenome Labs Ltd, Bangalore, Karnataka, India

[11] Wildlife Conservat Soc, Russia Program, New York, NY USA

[12] Cornell Univ, Coll Vet Med, Ithaca, NY 14853 USA

[13] Kerala Forest Dept, Waynad, India

[14] Aranyak, Gauhati, India

[15] CCMB, Lab Conservat Endangered Species, Hyderabad, India

[16] Omaha Zoo, Dept Genet, Omaha, NE USA

[17] Inst Conservat Res, San Diego Zoo, Escondido, CA USA

[18] Wildlife Inst India, Dehra Dun, Uttarakhand, India

来源：

MOLECULAR BIOLOGY AND EVOLUTION | 2021年 / 38卷 / 06期

基金：

英国惠康基金;

关键词：

conservation genomics; carnivores; population decline; GENOMES REVEAL; POPULATION; ADAPTATION; INFERENCE; EXTINCTION; SIGNATURES; DISPERSAL; LANDSCAPE; FORMAT;

D O I：

10.1093/molbev/msab032

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Species conservation can be improved by knowledge of evolutionary and genetic history. Tigers are among the most charismatic of endangered species and garner significant conservation attention. However, their evolutionary history and genomic variation remain poorly known, especially for Indian tigers. With 70% of the world's wild tigers living in India, such knowledge is critical. We re-sequenced 65 individual tiger genomes representing most extant subspecies with a specific focus on tigers from India. As suggested by earlier studies, we found strong genetic differentiation between the putative tiger subspecies. Despite high total genomic diversity in India, individual tigers host longer runs of homozygosity, potentially suggesting recent inbreeding or founding events, possibly due to small and fragmented protected areas. We suggest the impacts of ongoing connectivity loss on inbreeding and persistence of Indian tigers be closely monitored. Surprisingly, demographic models suggest recent divergence (within the last 20,000 years) between subspecies and strong population bottlenecks. Amur tiger genomes revealed the strongest signals of selection related to metabolic adaptation to cold, whereas Sumatran tigers show evidence of weak selection for genes involved in body size regulation. We recommend detailed investigation of local adaptation in Amur and Sumatran tigers prior to initiating genetic rescue.

引用

页码：2366 / 2379

页数：14

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