Carbolithiation of vinyl pyridines as a route to 7-azaindoles

被引：25

作者：

Cottineau, B ^{[1
]}

O'Shea, DF ^{[1
]}

机构：

[1] Natl Univ Ireland Univ Coll Dublin, Dept Chem, Conway Inst, Ctr Synth & Chem Biol, Dublin 4, Ireland

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 11期

关键词：

7-azaindole; carbolithiation; cascade reaction;

D O I：

10.1016/j.tetlet.2005.01.046

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An effective synthesis of the 7-azaindole ring system has been developed from substituted 2-amino-3-vinyl pyridines. The methodology involves a novel cascade reaction sequence of controlled carbolithiation of the vinyl double bond, subsequent trapping of the intermediate organolithium with a suitable electrophile, followed by ring closure and dehydration. (C) 2005 Elsevier Ltd. All rights reserved.

引用

页码：1935 / 1938

页数：4

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