The role of the clinical pharmacist in the prevention of potential drug interactions in geriatric heart failure patients
被引:26
作者:
Georgiev, Kaloyan D.
论文数: 0引用数: 0
h-index: 0
机构:
Med Univ Prof Dr Paraskev Stoyanov, Fac Pharm, Dept Pharmaceut Technol, Varna, BulgariaMed Univ Prof Dr Paraskev Stoyanov, Fac Pharm, Dept Pharmaceut Technol, Varna, Bulgaria
Georgiev, Kaloyan D.
[1
]
Hvarchanova, Nadezhda
论文数: 0引用数: 0
h-index: 0
机构:
Med Univ Prof Dr Paraskev Stoyanov, Fac Pharm, Dept Pharmacol Toxicol & Pharmacotherapy, Varna, BulgariaMed Univ Prof Dr Paraskev Stoyanov, Fac Pharm, Dept Pharmaceut Technol, Varna, Bulgaria
Hvarchanova, Nadezhda
[2
]
Georgieva, Marieta
论文数: 0引用数: 0
h-index: 0
机构:
Med Univ Prof Dr Paraskev Stoyanov, Fac Pharm, Dept Pharmacol Toxicol & Pharmacotherapy, Varna, BulgariaMed Univ Prof Dr Paraskev Stoyanov, Fac Pharm, Dept Pharmaceut Technol, Varna, Bulgaria
Georgieva, Marieta
[2
]
Kanazirev, Branimir
论文数: 0引用数: 0
h-index: 0
机构:
Med Univ Prof Dr Paraskev Stoyanov, Fac Med, UMHAT St Marina, Dept Internal Med, Varna, BulgariaMed Univ Prof Dr Paraskev Stoyanov, Fac Pharm, Dept Pharmaceut Technol, Varna, Bulgaria
Kanazirev, Branimir
[3
]
机构:
[1] Med Univ Prof Dr Paraskev Stoyanov, Fac Pharm, Dept Pharmaceut Technol, Varna, Bulgaria
[2] Med Univ Prof Dr Paraskev Stoyanov, Fac Pharm, Dept Pharmacol Toxicol & Pharmacotherapy, Varna, Bulgaria
[3] Med Univ Prof Dr Paraskev Stoyanov, Fac Med, UMHAT St Marina, Dept Internal Med, Varna, Bulgaria
Background The treatment of heart failure patients is very complex and includes lifestyle modification as well as different pharmacological therapies. Polypharmacy is very common in such patients and they are at increased risk of potential drug-drug interactions and associated effects such as poor adherence, compliance and adverse events. Objective The aim of the present study is to investigate retrospectively the prescribed pharmacotherapy of the hospital discharged heart failure patients for possible drug interactions. Settings Clinic for Cardiology of the "Saint Marina" University Hospital in Varna, Bulgaria. Method Lexicomp((R)) Drug interaction software was used for screening potential drug-drug interactions. Logistic regression was applied to determine the odds ratio for the association between the age and number of drugs taken and the number of potential drug-drug interactions. Main outcome measure Incidence and type of pDDIs in geriatric heart failure patients. Results A retrospective study was conducted by reviewing the medical records of 248 selected heart failure patients for the prescribed medicines for a 1-year period (January 2015-December 2015). The total number of potential drug-drug interactions was 1532, or approximately 6.28 (+/- 4.72 SD) per one person. The range of prescribed drugs was between three and fourteen, 92% of them have been taking more than five medicines, an average of 7.12 (+/- 2.07 SD) per patient. The average age was 72.35 (+/- 10.16 SD). The results have shown stronger association between the number of drugs taken (more than 7) and the occurrence of potential drug-drug interactions (more than 10)-37.84 (95% CI 9.012-158.896, P <= 0.001). No statistically significant differences were found between age and occurrence of potential drug-drug interactions (more than 10)-1.008 (95% CI 0.441-2.308, P=0.848). Conclusion The incidence of drug-drug interactions in heart failure patients is high. The clinical pharmacist, as a part of the multidisciplinary team, could reduce medication-related problems, such as drug interactions, and to optimize drug therapy by checking the treatment prescribed at the discharge of these patients.
机构:
Duke Univ, Sch Med, Dept Med, Div Cardiol,Duke Clin Res Inst, Durham, NC 27706 USADuke Univ, Sch Med, Dept Med, Div Cardiol,Duke Clin Res Inst, Durham, NC 27706 USA
Cooper, Lauren B.
Hernandez, Adrian F.
论文数: 0引用数: 0
h-index: 0
机构:
Duke Univ, Sch Med, Dept Med, Div Cardiol,Duke Clin Res Inst, Durham, NC 27706 USADuke Univ, Sch Med, Dept Med, Div Cardiol,Duke Clin Res Inst, Durham, NC 27706 USA
机构:
Univ Toronto, Fac Med, Leslie Dan Fac Pharm, Toronto, ON, Canada
McMaster Univ, Dept Family Med, Hamilton, ON, Canada
Univ Waterloo, Sch Pharm, Waterloo, ON, CanadaUniv Toronto, Fac Med, Leslie Dan Fac Pharm, Toronto, ON, Canada
Dolovich, Lisa
论文数: 引用数:
h-index:
机构:
Austin, Zubin
论文数: 引用数:
h-index:
机构:
Waite, Nancy
Chang, Feng
论文数: 0引用数: 0
h-index: 0
机构:
Univ Waterloo, Sch Pharm, Waterloo, ON, CanadaUniv Toronto, Fac Med, Leslie Dan Fac Pharm, Toronto, ON, Canada
Chang, Feng
Farrell, Barbara
论文数: 0引用数: 0
h-index: 0
机构:
Univ Waterloo, Sch Pharm, Waterloo, ON, Canada
Univ Ottawa, Dept Family Med, Ottawa, ON, Canada
Bruyere Res Inst, Ottawa, ON, CanadaUniv Toronto, Fac Med, Leslie Dan Fac Pharm, Toronto, ON, Canada
Farrell, Barbara
Grindrod, Kelly
论文数: 0引用数: 0
h-index: 0
机构:
Univ Waterloo, Sch Pharm, Waterloo, ON, CanadaUniv Toronto, Fac Med, Leslie Dan Fac Pharm, Toronto, ON, Canada
Grindrod, Kelly
Houle, Sherilyn
论文数: 0引用数: 0
h-index: 0
机构:
Univ Waterloo, Sch Pharm, Waterloo, ON, CanadaUniv Toronto, Fac Med, Leslie Dan Fac Pharm, Toronto, ON, Canada
Houle, Sherilyn
McCarthy, Lisa
论文数: 0引用数: 0
h-index: 0
机构:
Univ Toronto, Fac Med, Leslie Dan Fac Pharm, Toronto, ON, Canada
Univ Toronto, Fac Med, Dept Family Med & Community Med, Toronto, ON, Canada
Womens Coll Hosp, Womens Coll Res Inst, Toronto, ON, CanadaUniv Toronto, Fac Med, Leslie Dan Fac Pharm, Toronto, ON, Canada
McCarthy, Lisa
MacCallum, Lori
论文数: 0引用数: 0
h-index: 0
机构:
Univ Toronto, Fac Med, Leslie Dan Fac Pharm, Toronto, ON, Canada
Univ Toronto, Fac Med, Banting & Best Diabet Ctr, Toronto, ON, Canada
Toronto Gen Hosp, Res Inst, Toronto, ON, CanadaUniv Toronto, Fac Med, Leslie Dan Fac Pharm, Toronto, ON, Canada
机构:
Duke Univ, Sch Med, Dept Med, Div Cardiol,Duke Clin Res Inst, Durham, NC 27706 USADuke Univ, Sch Med, Dept Med, Div Cardiol,Duke Clin Res Inst, Durham, NC 27706 USA
Cooper, Lauren B.
Hernandez, Adrian F.
论文数: 0引用数: 0
h-index: 0
机构:
Duke Univ, Sch Med, Dept Med, Div Cardiol,Duke Clin Res Inst, Durham, NC 27706 USADuke Univ, Sch Med, Dept Med, Div Cardiol,Duke Clin Res Inst, Durham, NC 27706 USA
机构:
Univ Toronto, Fac Med, Leslie Dan Fac Pharm, Toronto, ON, Canada
McMaster Univ, Dept Family Med, Hamilton, ON, Canada
Univ Waterloo, Sch Pharm, Waterloo, ON, CanadaUniv Toronto, Fac Med, Leslie Dan Fac Pharm, Toronto, ON, Canada
Dolovich, Lisa
论文数: 引用数:
h-index:
机构:
Austin, Zubin
论文数: 引用数:
h-index:
机构:
Waite, Nancy
Chang, Feng
论文数: 0引用数: 0
h-index: 0
机构:
Univ Waterloo, Sch Pharm, Waterloo, ON, CanadaUniv Toronto, Fac Med, Leslie Dan Fac Pharm, Toronto, ON, Canada
Chang, Feng
Farrell, Barbara
论文数: 0引用数: 0
h-index: 0
机构:
Univ Waterloo, Sch Pharm, Waterloo, ON, Canada
Univ Ottawa, Dept Family Med, Ottawa, ON, Canada
Bruyere Res Inst, Ottawa, ON, CanadaUniv Toronto, Fac Med, Leslie Dan Fac Pharm, Toronto, ON, Canada
Farrell, Barbara
Grindrod, Kelly
论文数: 0引用数: 0
h-index: 0
机构:
Univ Waterloo, Sch Pharm, Waterloo, ON, CanadaUniv Toronto, Fac Med, Leslie Dan Fac Pharm, Toronto, ON, Canada
Grindrod, Kelly
Houle, Sherilyn
论文数: 0引用数: 0
h-index: 0
机构:
Univ Waterloo, Sch Pharm, Waterloo, ON, CanadaUniv Toronto, Fac Med, Leslie Dan Fac Pharm, Toronto, ON, Canada
Houle, Sherilyn
McCarthy, Lisa
论文数: 0引用数: 0
h-index: 0
机构:
Univ Toronto, Fac Med, Leslie Dan Fac Pharm, Toronto, ON, Canada
Univ Toronto, Fac Med, Dept Family Med & Community Med, Toronto, ON, Canada
Womens Coll Hosp, Womens Coll Res Inst, Toronto, ON, CanadaUniv Toronto, Fac Med, Leslie Dan Fac Pharm, Toronto, ON, Canada
McCarthy, Lisa
MacCallum, Lori
论文数: 0引用数: 0
h-index: 0
机构:
Univ Toronto, Fac Med, Leslie Dan Fac Pharm, Toronto, ON, Canada
Univ Toronto, Fac Med, Banting & Best Diabet Ctr, Toronto, ON, Canada
Toronto Gen Hosp, Res Inst, Toronto, ON, CanadaUniv Toronto, Fac Med, Leslie Dan Fac Pharm, Toronto, ON, Canada