Preparation of Near-Infrared Quantum Dots-Herceptin Conjugates for Cancer Imaging

被引：5
|
作者：
Lee, Dong Kwan [1 ]
Lee, Yong-kyu [1 ]
机构：
[1] Chungju Natl Univ, Dept Chem & Biol Engn, Chungbuk 380702, South Korea
来源：
MACROMOLECULAR RESEARCH | 2010年 / 18卷 / 07期
关键词：
near-infrared quantum dot; targeting; imaging; HER-2; receptor; cancer therapy; NANOPARTICLES; NANOCRYSTALS; ACID;
D O I：
10.1007/s13233-010-0707-6
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
High-quality, near-infrared CdTe/CdSe core/shell quantum dots (QDs) formed in organic solvents can be dissolved completely in water using amphiphilic polymers, such as octylamine-modified poly(acrylic acid). The native hydrophobic ligands of QDs may be retained and used to interact with an amphiphilic polymer. Neutralized, octylamine-modified poly(acrylic acid) complexes hydrophobically capped CdTe/CdSe QDs, making them water-soluble. Fluorescence spectrophotometry showed that the quantum dot-polymer composites have strong photo-luminescence and are very stable in aqueous solutions. The surfaces of the water-soluble QDs can be conjugated to biomolecules, such as antibodies that target the human breast cancer cell line SK-BR-3, which is over expresses the HER-2 receptor (epidermal growth factor receptor-2). QD-Bioconjugates were characterized by UV-Vis spectroscopy, fluorescence photospectroscopy and confocal microscopy. Finally, it was confirmed that QDs-antibody bioconjugates efficiently labeled the cell membranes (targeted to HER-2 receptors) by comparing the water soluble QDs and QDs-antibody bioconjugates.
引用
收藏
页码：641 / 647
页数：7
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