Safety Assessment of Tocopherols and Tocotrienols as Used in Cosmetics

被引：26

作者：

Fiume, Monice M. ^{[1
]}

Bergfeld, Wilma F. ^{[1
]}

Belsito, Donald V. ^{[1
]}

Hill, Ronald A. ^{[1
]}

Klaassen, Curtis D. ^{[1
]}

Liebler, Daniel C. ^{[1
]}

Marks, James G., Jr. ^{[1
]}

Shank, Ronald C. ^{[1
]}

Slaga, Thomas J. ^{[1
]}

Snyder, Paul W. ^{[1
]}

Andersen, F. Alan ^{[1
]}

Heldreth, Bart ^{[1
]}

机构：

[1] Cosmet Ingredient Rev, Suite 1200,1620L St NW, Washington, DC 20036 USA

来源：

INTERNATIONAL JOURNAL OF TOXICOLOGY | 2018年 / 37卷

关键词：

tocopherols; tocotrienols; safety; cosmetics; VITAMIN-E ACETATE; ALLERGIC CONTACT-DERMATITIS; ALPHA-TOCOPHEROL; TOPICAL APPLICATION; TISSUE DISTRIBUTION; GAMMA-TOCOTRIENOLS; OXIDATIVE DAMAGE; ORAL TOXICITY; SKIN; RATS;

D O I：

10.1177/1091581818794455

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The Cosmetic Ingredient Review (CIR) Expert Panel (Panel) assessed the safety of 14 tocopherols and tocotrienols and concluded these ingredients are safe as used in cosmetics. The tocopherols are reported to function in cosmetics as antioxidants or skin-conditioning agents; in contrast, tocotrienols are not reported to function as an antioxidants in cosmetics but as a light stabilizer, oral care agent, or skin-conditioning agent. The Panel reviewed the new and existing animal and clinical data to determine the safety of these ingredients and found it appropriate to extrapolate the existing information to conclude on the safety of all the tocopherols and tocotrienols.

引用

页码：61S / 94S

页数：34

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