Ceftriaxone reverses deficits of behavior and neurogenesis in an MPTP-induced rat model of Parkinson's disease dementia

被引：27
作者：
Hsieh, Ming-Hong [1 ]
Meng, Wan-Yun [2 ]
Liao, Wen-Chieh [3 ]
Weng, Jun-Cheng [4 ]
Li, Hsin-Hua [5 ]
Su, Hong-Lin [6 ]
Lin, Chih-Li [5 ]
Hung, Ching-Sui [7 ]
Ho, Ying-Jui [2 ]
机构：
[1] Chung Shan Med Univ, Sch Med, Dept Psychiat, Chung Shan Med Univ Hosp, Taichung 402, Taiwan
[2] Chung Shan Med Univ, Chung Shan Med Univ Hosp, Dept Psychol, Taichung 402, Taiwan
[3] Chung Shan Med Univ, Chung Shan Med Univ Hosp, Dept Anat, Dept Pediat,Fac Anat, Taichung 402, Taiwan
[4] Chung Shan Med Univ, Dept Med Imaging & Radiol Sci, Taichung 402, Taiwan
[5] Chung Shan Med Univ, Inst Med, Taichung 402, Taiwan
[6] Natl Chung Hsing Univ, Agr Biotechnol Ctr, Dept Life Sci, Taichung 402, Taiwan
[7] Taipei City Hosp, Occupat Safety & Hlth Off, Taipei 10341, Taiwan
来源：
BRAIN RESEARCH BULLETIN | 2017年 / 132卷
关键词：
Ceftriaxone; Neurodegeneration; Neurogenesis; Neuroprotection; Parkinson's disease dementia; GLUTAMATE TRANSPORTER EXPRESSION; BETA-LACTAM ANTIBIOTICS; ADULT SUBSTANTIA-NIGRA; INDUCED ANIMAL-MODEL; EPISODIC-LIKE MEMORY; NEURAL STEM-CELLS; BASAL GANGLIA; SUBTHALAMIC NUCLEUS; OBJECT-RECOGNITION; MOUSE MODEL;
D O I：
10.1016/j.brainresbull.2017.05.015
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Hyperactivity of the glutamatergic system is involved in excitotoxicity and neurodegeneration in Parkinson's disease (PD) so that glutamatergic modulation maybe a potential therapeutic target for PD. Ceftriaxone (CEF) has been reported to increase glutamate uptake by increasing glutamate transporter expression and has been demonstrated neuroprotective effects in animal study. The aim of this study was to determine the effects of CEF on behavior and neurogenesis in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD rat model. MPTP was stereotaxically injected into the substantia nigra pars compacta (SNc) of male Wistar rats. Starting on the same day after MPTP lesioning (day 0), the rats were injected daily with either CEF or saline for 14 days and underwent a T-maze test on days 8-10 and an object recognition test on days 12-14, then the brain was taken for histological evaluation on day 15. The results showed that MPTP lesioning resulted in decreased motor function, working memory, and object recognition and reduced neurogenesis in the substantial nigra and dentate gyrus of the hippocampus. These behavioral and neuronal changes were prevented by CEF treatment. To our knowledge, this is the first study showing that CEF prevents loss of neurogenesis in the brain of PD rats. CEF may therefore have clinical potential in the treatment of PD.
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收藏
页码：129 / 138
页数：10
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