Polo-like kinase 1 is essential to DNA damage recovery

被引：4

作者：

Liu, Lin ^{[1
]}

Zhang, Min ^{[1
]}

Zou, Ping ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Hematol, Wuhan 430074, Hubei, Peoples R China

来源：

LEUKEMIA & LYMPHOMA | 2010年 / 51卷 / 06期

关键词：

Polo-like kinase 1; DNA damage; cell cycle; apoptosis; CELLULAR-RESPONSES; CANCER-CELLS; PLK1; APOPTOSIS; ATM; CYTOKINESIS; REVEALS; TARGET; P53;

D O I：

10.3109/10428191003706939

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Radiation treatment and chemotherapy can both cause DNA damage to tumor cells. Tumor cells have specific self-protecting mechanisms to escape death. In this study, we explored the effects of polo-like kinase 1 on the DNA damage recovery system in lymphoma cell lines. DNA damage caused inhibition of polo-like kinase 1 activity and induced cell cycle arrest at the G2/M phase. Once the DNA damage was repaired, polo-like kinase 1 activity was restored and cell cycle arrest was removed. Unexpectedly, polo-like kinase 1 depletion hampered the cell cycle progress of cells recovered from DNA damage, and induced apoptosis.

引用

页码：1079 / 1089

页数：11

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