Cholesterol and caveolae: structural and functional relationships

被引：182

作者：

Fielding, CJ ^{[1
]}

Fielding, PE

机构：

[1] Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 2000年 / 1529卷 / 1-3期

关键词：

caveolae; caveolin; free cholesterol; raft;

D O I：

10.1016/S1388-1981(00)00150-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Caveolae are free cholesterol (FC)- and sphingolipid-rich surface microdomains abundant in most peripheral cells. Caveolin, a FC binding protein, is a major structural element of these domains. Caveolae serve as portals to regulate cellular FC homeostasis, possibly via their association with ancillary proteins including scavenger receptor B1. The FC content of caveolae regulates the transmission of both extracellular receptor-mediated and endogenous signal transduction via changes in the composition of caveolin-associated complexes of signaling intermediates. By controlling surface FC content,reporting membrane changes by signal transduction to the nucleus, and regulating signal traffic in response to extracellular stimuli, caveolae exert a multifaceted influence on cell physiology including growth and cell division, adhesion, and hormonal response. Cell surface lipid 'rafts' may assume many of the functions of caveolae in cells with low levels of caveolin. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：210 / 222

页数：13

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