Generation of skeletal muscle stem/progenitor cells from murine induced pluripotent stem cells

被引：122
作者：
Mizuno, Yuta
Chang, Hsi
Umeda, Katsutsugu
Niwa, Akira
Iwasa, Toru
Awaya, Tomonari
Fukada, So-ichiro [4 ]
Yamamoto, Hiroshi [4 ]
Yamanaka, Shinya [2 ,3 ,5 ]
Nakahata, Tatsutoshi [3 ]
Heike, Toshio [1 ]
机构：
[1] Kyoto Univ, Dept Pediat, Grad Sch Med, Sakyo Ku, Kyoto 6068507, Japan
[2] Kyoto Univ, Dept Stem Cell Biol, Inst Frontier Med Sci, Kyoto 6068507, Japan
[3] Kyoto Univ, Ctr iPS Cell Res & Applicat, Inst Integrated Cell Mat Sci, Kyoto 6068507, Japan
[4] Osaka Univ, Dept Immunol, Grad Sch Pharmaceut Sci, Osaka, Japan
[5] Japan Sci & Technol Agcy, CREST, Kawaguchi, Saitama, Japan
来源：
FASEB JOURNAL | 2010年 / 24卷 / 07期
关键词：
Duchenne muscular dystrophy; Pax7; long-term engraftment; no teratoma formation; high engraftment efficiency; BONE-MARROW; DYSTROPHIN EXPRESSION; SATELLITE CELLS; MOUSE; REGENERATION; FIBROBLASTS; PROGENITORS; CULTURE; MDX;
D O I：
10.1096/fj.09-137174
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Induced pluripotent stem (iPS) cells, which are a type of pluripotent stem cell generated from reprogrammed somatic cells, are expected to have potential for patient-oriented disease investigation, drug screening, toxicity tests, and transplantation therapies. Here, we demonstrated that murine iPS cells have the potential to develop in vitro into skeletal muscle stem/progenitor cells, which are almost equivalent to murine embryonic stem cells. Cells with strong in vitro myogenic potential effectively were enriched by fluorescence-activated cell sorting using the anti-satellite cell antibody SM/C-2.6. Furthermore, on transplantation into mdx mice, SM/C-2.6(+) cells exerted sustained myogenic lineage differentiation in injured muscles, while providing long-lived muscle stem cell support. Our data suggest that iPS cells have the potential to be used in clinical treatment of muscular dystrophies.-Mizuno, Y., Chang, H., Umeda, K., Niwa, A., Iwasa, T., Awaya, T., Fukada, S., Yamamoto, H., Yamanaka, S., Nakahata, T., Heike, T. Generation of skeletal muscle stem/progenitor cells from murine induced pluripotent stem cells. FASEB J. 24, 2245-2253 (2010). www.fasebj.org
引用
收藏
页码：2245 / 2253
页数：9
相关论文
共 50 条
[41]   Generation of Induced Pluripotent Stem Cells from the Prairie Vole [J].
Manoli, Devanand S. ;
Subramanyam, Deepa ;
Carey, Catriona ;
Sudin, Erik ;
Van Westerhuyzen, Julie A. ;
Bales, Karen L. ;
Blelloch, Robert ;
Shah, Nirao M. .
PLOS ONE, 2012, 7 (05)
[42]   Generation of Mice Derived from Induced Pluripotent Stem Cells [J].
Boland, Michael J. ;
Hazen, Jennifer L. ;
Nazor, Kristopher L. ;
Rodriguez, Alberto R. ;
Martin, Greg ;
Kupriyanov, Sergey ;
Baldwin, Kristin K. .
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 2012, (69)
[43]   Generation of retinal cells from pluripotent stem cells [J].
Jin, Zi-Bing ;
Takahashi, Masayo .
FUNCTIONAL NEURAL TRANSPLANTATION III PRIMARY AND STEM CELL THERAPIES FOR BRAIN REPAIR, PT II, 2012, 201 :171-181
[44]   Involvement of β-adrenoceptors in the differentiation of human induced pluripotent stem cells into mesodermal progenitor cells [J].
Ishizuka, Toshiaki ;
Goshima, Hazuki ;
Ozawa, Ayako ;
Watanabe, Yasuhiro .
EUROPEAN JOURNAL OF PHARMACOLOGY, 2014, 740 :28-34
[45]   Generation of Induced Pluripotent Stem Cells from Human Kidney Mesangial Cells [J].
Song, Bi ;
Niclis, Jonathan C. ;
Alikhan, Maliha A. ;
Sakkal, Samy ;
Sylvain, Aude ;
Kerr, Peter G. ;
Laslett, Andrew L. ;
Bernard, Claude A. ;
Ricardo, Sharon D. .
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2011, 22 (07) :1213-1220
[46]   Generation of functional human thymic cells from induced pluripotent stem cells [J].
Ramos, Stephan A. ;
Morton, John J. ;
Yadav, Prabha ;
Reed, Brendan ;
Alizadeh, Sheila, I ;
Shilleh, Ali H. ;
Perrenoud, Loni ;
Jaggers, James ;
Kappler, John ;
Jimeno, Antonio ;
Russ, Holger A. .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2022, 149 (02) :767-+
[47]   Generation of porcine induced-pluripotent stem cells from Sertoli cells [J].
Setthawong, Piyathip ;
Phakdeedindan, Praopilas ;
Tiptanavattana, Narong ;
Rungarunlert, Sasitorn ;
Techakumphu, Mongkol ;
Tharasanit, Theerawat .
THERIOGENOLOGY, 2019, 127 :32-40
[48]   Small Molecule Inhibitors Promote Efficient Generation of Induced Pluripotent Stem Cells From Human Skeletal Myoblasts [J].
Trokovic, Ras ;
Weltner, Jere ;
Manninen, Tuula ;
Mikkola, Milla ;
Lundin, Karolina ;
Hamalainen, Riikka ;
Suomalainen, Anu ;
Otonkoski, Timo .
STEM CELLS AND DEVELOPMENT, 2013, 22 (01) :114-123
[49]   Human and mouse skeletal muscle stem and progenitor cells in health and disease [J].
Mierzejewski, Bartosz ;
Archacka, Karolina ;
Grabowska, Iwona ;
Florkowska, Anita ;
Ciemerych, Maria Anna ;
Brzoska, Edyta .
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2020, 104 :93-104
[50]   Thyroid cell differentiation from murine induced pluripotent stem cells [J].
Ma, Risheng ;
Morshed, Syed A. ;
Latif, Rauf ;
Davies, Terry F. .
FRONTIERS IN ENDOCRINOLOGY, 2015, 6
12345