Polymodal Gating of the TREK-2 K2P Potassium Channel Involves Structurally Distinct Open States

被引:0
|
作者
McClenaghan, Conor [1 ]
Schewe, Marcus [2 ]
Baukrowitz, Thomas [2 ]
Tucker, Stephen J. [1 ]
机构
[1] Univ Oxford, Dept Phys, Oxford, England
[2] Univ Kiel, Inst Physiol, Kiel, Germany
关键词
D O I
10.1016/j.bpj.2015.11.3241
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
2997-Pos
引用
收藏
页码:607A / 607A
页数:1
相关论文
共 50 条
  • [31] Norfluoxetine inhibits TREK-2 K2P channels by multiple mechanisms including state-independent effects on the selectivity filter gate
    Proks, Peter
    Schewe, Marcus
    Conrad, Linus J.
    Rao, Shanlin
    Rathje, Kristin
    Rodstrom, Karin E. J.
    Carpenter, Elisabeth P.
    Baukrowitz, Thomas
    Tucker, Stephen J.
    JOURNAL OF GENERAL PHYSIOLOGY, 2021, 153 (08):
  • [32] Separate Gating Mechanisms Mediate the Regulation of K2P Potassium Channel TASK-2 by Intra- and Extracellular pH
    Isabel Niemeyer, Maria
    Pablo Cid, L.
    Pena-Munzenmayer, Gaspar
    Sepulveda, Francisco V.
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (22) : 16467 - 16475
  • [33] Membrane phospholipids control activity of the mechanosensitive K2P channel TREK1
    Schmidpeter, Philipp
    Wague, Aboubacar
    Petroff, John T.
    Cheng, Wayland W.
    Nimigean, Crina M.
    Riegelhaupt, Paul M.
    BIOPHYSICAL JOURNAL, 2022, 121 (03) : 433A - 433A
  • [34] Expression and function of the two pore potassium (K2P) channels TREK-1 (KCNK2), TREK-2 (KCNK10) and TASK-3 (KCNK9) in ovarian cancer
    Innamaa, A.
    Jackson, L.
    Asher, V
    van Shalkwyk, G.
    Warren, A.
    Hay, D.
    Bali, A.
    Sowter, H.
    Khan, R.
    BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 2013, 120 (09) : E5 - E6
  • [35] Splice Variants of the K2P Channel TREK-1 Associated with Preterm Labor
    Wu, Yi-Ying
    Singer, Cherie A.
    Buxton, Iain L. O.
    REPRODUCTIVE SCIENCES, 2012, 19 (S3) : 200A - 200A
  • [37] 'C-type' closed state and gating mechanisms of K2P channels revealed by conformational changes of the TREK-1 channel
    Zhang, Qiansen
    Fu, Jie
    Zhang, Shaoying
    Guo, Peipei
    Liu, Shijie
    Shen, Juwen
    Guo, Jiangtao
    Yang, Huaiyu
    JOURNAL OF MOLECULAR CELL BIOLOGY, 2022, 14 (01)
  • [38] Sensing the Electrochemical K+ Gradient: The Voltage Gating Mechanism in K2P Potassium Channels
    Schewe, Marcus
    Nematian-Ardestani, Ehsan
    Linke, Thomas
    Benndorf, Klaus
    Tucker, Stephen J.
    Rapedius, Markus
    Baukrowitz, Thomas
    BIOPHYSICAL JOURNAL, 2015, 108 (02) : 427A - 428A
  • [39] Regulation and function of the two-pore-domain (K2P) potassium channel Trek-1 in alveolar epithelial cells
    Schwingshackl, Andreas
    Teng, Bin
    Ghosh, Manik
    West, Alina Nico
    Makena, Patrudu
    Gorantla, Vijay
    Sinclair, Scott E.
    Waters, Christopher M.
    AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2012, 302 (01) : L93 - L102
  • [40] The inhibitory effects of bupivacaine, levobupivacaine, and ropivacaine on K2P (two-pore domain potassium) channel TREK-1
    Hye Won Shin
    Jeong Seop Soh
    Hee Zoo Kim
    Jinpyo Hong
    Dong Ho Woo
    Jun Young Heo
    Eun Mi Hwang
    Jae-Yong Park
    C. Justin Lee
    Journal of Anesthesia, 2014, 28 : 81 - 86