Hooked! Modeling human disease in zebrafish

被引：364

作者：

Santoriello, Cristina ^{[5
]}

Zon, Leonard I. ^{[1
,2
,3
,4
,5
]}

机构：

[1] Childrens Hosp, Stem Cell Program, Boston, MA 02115 USA

[2] Childrens Hosp, Div Hematol Oncol, Boston, MA 02115 USA

[3] Dana Farber Canc Inst, Boston, MA 02115 USA

[4] Harvard Univ, Sch Med, Boston, MA USA

[5] Harvard Univ, Dept Stem Cell & Regenerat Biol, Cambridge, MA 02138 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2012年 / 122卷 / 07期

关键词：

DIAMOND-BLACKFAN ANEMIA; ZINC-FINGER NUCLEASES; RIBOSOMAL-PROTEIN S19; T-CELL LEUKEMIA; TRANSGENIC ZEBRAFISH; MUSCULAR-DYSTROPHY; HEART REGENERATION; MELANOMA-CELLS; POSITIONAL CLONING; GENE INACTIVATION;

D O I：

10.1172/JCI60434

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Zebrafish have been widely used as a model system for studying developmental processes, but in the last decade, they have also emerged as a valuable system for modeling human disease. The development and function of zebrafish organs are strikingly similar to those of humans, and the ease of creating mutant or transgenic fish has facilitated the generation of disease models. Here, we highlight the use of zebrafish for defining disease pathways and for discovering new therapies.

引用

页码：2337 / 2343

页数：7

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