Expression of cytokeratin-20 in pancreatic cancer:: An indicator of poor outcome after R0 resection

被引:10
作者
Schmitz-Winnenthal, FH
Volk, C
Helmke, B
Berger, S
Hinz, U
Koch, M
Weitz, J
Kleeff, J
Friess, H
Zöller, M
Büchler, MW
Z'graggen, K
机构
[1] Heidelberg Univ, Dept Pathol, D-6900 Heidelberg, Germany
[2] Heidelberg Univ, Dept Gen Surg, D-6900 Heidelberg, Germany
[3] German Canc Res Ctr, Div Tumorprogress & Immune Def, D-6900 Heidelberg, Germany
关键词
D O I
10.1016/j.surg.2005.06.058
中图分类号
R61 [外科手术学];
学科分类号
摘要
Background. After complete removal of the neoplasm (RO resection), approximately 80% of pancreatic cancer patients will die of the disease within 5 years. The expression panel of cytokeralins (CK) is linked closely with cell differentiation. The aim of the study was to investigate the expression of CK-20 in pancreatic cancer tissue and to correlate CK-20 expression with survival in R0-resected pancreatic cancer patients. Methods. Tissue samples of 63 patients with pancreatic cancer were subjected to CK-20 reverse transcription polymerase chain reaction. Thirty-four of 63 patients underwent RO resection and were followed-up for survival statistics. From these 34 patients, 26 (76%) neoplasms were CK-20 positive and 8 (24%) samples were CK-20 negative. The mean follow-up period for the entire group was 17 months (range, 4-36 mo), the follow-up period in censored patients was 23 months (range, 10-36 mo). Results. In the R0-resected group, 3 of 8 (38%) patients with CK-20-negative neoplasms, and 16 of 26 (62%) patients with CK-20-positive neoplasms (P = .15) died of recurrent disease. The median survival time of patients with CK-20-positive neoplasms was 13 months (range, 4-36), the median survival in R0-resected patients with CK-20-negative neoplasm was 26 months (range, 13-35; P =. 06). The survival difference observed in patients with CK-20-negative neoplasms could not be attributed to intergroup variations in tumor stage or tumor grade. Conclusions. A majority of primary ductal pancreatic adenocarcinomas express CK-20. This seems to be associated with poorer survival in R0-resecled patients. Our data suggest that ductal pancreatic adenocarcinomas negative for CK-20 constitute a subgroup of patients showing a more favorable disease outcome. The expression of CK-20 in resected pancreatic cancer may be of interest as a prognostic parameter.
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页码:104 / 108
页数:5
相关论文
共 40 条
[1]  
AISON DC, 1998, J SURG ONCOL, V67, P151
[2]   THE MOLECULAR-BIOLOGY OF INTERMEDIATE FILAMENT PROTEINS [J].
ALBERS, K ;
FUCHS, E .
INTERNATIONAL REVIEW OF CYTOLOGY-A SURVEY OF CELL BIOLOGY, 1992, 134 :243-+
[3]   DPC4/Smad4 expression and outcome in pancreatic ductal adenocarcinoma [J].
Biankin, AV ;
Morey, AL ;
Lee, CS ;
Kench, JG ;
Biankin, SA ;
Hook, HC ;
Head, DR ;
Hugh, TB ;
Sutherland, RL ;
Henshall, SM .
JOURNAL OF CLINICAL ONCOLOGY, 2002, 20 (23) :4531-4542
[4]   Relationship between hospital volume and late survival after pancreaticoduodenectomy [J].
Birkmeyer, JD ;
Warshaw, AL ;
Finlayson, SRG ;
Grove, MR ;
Tosteson, ANA .
SURGERY, 1999, 126 (02) :178-183
[5]  
Bouwens L, 2004, CELL BIOCHEM BIOPHYS, P81
[6]   CYTOKERATINS AS MARKERS OF DUCTAL CELL-DIFFERENTIATION AND ISLET NEOGENESIS IN THE NEONATAL RAT PANCREAS [J].
BOUWENS, L ;
WANG, RN ;
DEBLAY, E ;
PIPELEERS, DG ;
KLOPPEL, G .
DIABETES, 1994, 43 (11) :1279-1283
[7]  
Bouwens L, 1998, J PATHOL, V184, P234
[8]   TREATMENT AND SURVIVAL IN 13560 PATIENTS WITH PANCREATIC-CANCER, AND INCIDENCE OF THE DISEASE, IN THE WEST MIDLANDS - AN EPIDEMIOLOGIC-STUDY [J].
BRAMHALL, SR ;
ALLUM, WH ;
JONES, AG ;
ALLWOOD, A ;
CUMMINS, C ;
NEOPTOLEMOS, JP .
BRITISH JOURNAL OF SURGERY, 1995, 82 (01) :111-115
[9]   Changes in morbidity after pancreatic resection -: Toward the end of completion pancreatectomy [J].
Büchler, MW ;
Wagner, M ;
Schmied, BM ;
Uhl, W ;
Friess, H ;
Z'graggen, K .
ARCHIVES OF SURGERY, 2003, 138 (12) :1310-1314
[10]  
DIGIUSEPPE JA, 1996, ADV ANAT PATHOL, V3, P139