Attenuation of morphine withdrawal signs by muscimol in the locus coeruleus of rats

被引：18

作者：

Mirzaii-Dizgah, Iraj ^{[2
]}

Karimian, Seyed Morteza ^{[1
]}

Hajimashhadi, Zahra ^{[1
]}

Riahi, Esmail ^{[1
]}

Ghasemi, Tayeb ^{[1
]}

机构：

[1] Univ Tehran Med Sci, Sch Med, Dept Physiol, Tehran, Iran

[2] Qom Univ Med Sci, Sch Med, Dept Physiol, Qom, Iran

来源：

BEHAVIOURAL PHARMACOLOGY | 2008年 / 19卷 / 03期

关键词：

gamma-amino-butyric acid; locus coeruleus; morphine; muscimol; naloxone; rat; withdrawal;

D O I：

10.1097/FBP.0b013e3282fe8849

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

This study examined the effects of intra-locus coeruleus injection of a gamma-amino-butyric acid type A (GABA(A)) receptor agonist on naloxone-induced withdrawal signs of morphine-dependent rats. Twenty different withdrawal signs were assessed. The total withdrawal score was calculated and used as an index of withdrawal intensity. The gamma-amino-butyric acid agonist and antagonists were injected 15 and 30 min before naloxone injection, respectively. Muscimol, a GABAA agonist (25, 50, and 100 ng/site), decreased the total withdrawal score in a dose-independent manner, whereas bicuculline (0.367, 3.67, and 36.7ng/site), a GABAA antagonist, and CGP35348 (48.6 ng/site), a gamma-amino-butyric acid type B antagonist, alone had no effects. On the other hand, muscimol effects were reversed by CG P35348 (48.6 ng/site) but not by bicuculline (36.7 ng/site). It may be concluded that the effects of muscimol were antagonized by gamma-amino-butyric acid type B but not by GABAA receptor antagonists. The mechanism involved seems to be intricate and needs further study.

引用

页码：171 / 175

页数：5

共 32 条

[1]

Barnard EA, 1998, PHARMACOL REV, V50, P291

[2] CATECHOLAMINERGIC AND GABAERGIC ANATOMICAL RELATIONSHIP IN THE RAT SUBSTANTIA NIGRA, LOCUS COERULEUS, AND HYPOTHALAMIC MEDIAN-EMINENCE - IMMUNOCYTOCHEMICAL VISUALIZATION OF BIOSYNTHETIC-ENZYMES ON SERIAL SEMITHIN PLASTIC-EMBEDDED SECTIONS [J].