Insulin promotes bone formation in augmented maxillary sinus in diabetic rabbits

被引:22
作者
Hou, C. -J. [1 ]
Liu, J. -L. [1 ]
Li, X. [1 ]
Bi, L. -J. [1 ]
机构
[1] Harbin Med Coll, Affiliated Hosp 4, Dept Stomatol, Harbin, Peoples R China
关键词
diabetes mellitus; bone formation; maxillary sinus floor elevation; osteocalcin; osteoblast; OSTEOBLAST-LIKE CELLS; GROWTH-FACTOR-I; EXTRACELLULAR GLUCOSE; FLOOR ELEVATION; EXPRESSION; DIFFERENTIATION; RAT; INHIBITION; RECEPTORS; CARTILAGE;
D O I
10.1016/j.ijom.2011.10.004
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
The role of insulin during the formation of bone in the augmented space of the maxillary sinus in patients with diabetes is unclear. The authors compared the differences in bone formation after maxillary sinus floor elevation in diabetic and healthy animals and evaluated the effects of insulin on osteogenesis and the differentiation and activities of the osteoblasts. 10 male Japanese white rabbits were divided into two groups after diabetic induction by a single injection of monohydrated alloxan and having maintained steady blood glucose levels. The groups included the diabetes mellitus group (DM; n = 5) and the DM + insulin group (n = 5); another five healthy rabbits comprised the control group. Maxillary sinus floor elevation was performed by grafting hydroxyapatite particles. Compared with the control group, the newly formed bone area, number of blood vessels and osteoblasts, collagen 1 content and serum osteocalcin levels were significantly decreased in DM rabbits (P < 0.01). Insulin treatment reversed the decrease in bone formation, blood vessels, osteoblasts, collagen I and serum osteocalcin (P < 0.01). Insulin treatment also promoted osteogenesis in the augmented space of the diabetic rabbits, which might have resulted from promotion of osteoblast differentiation and upregulation of neovascularization.
引用
收藏
页码:400 / 407
页数:8
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