Very high birth weight of offspring is associated with an increased risk of leukemia in their mothers: Results of a population-based cohort study

被引：2

作者：

Paltiel, Ora ^{[1
,2
]}

Yanetz, Rebecca ^{[1
]}

Calderon-Margalit, Ronit ^{[1
]}

Manor, Orly ^{[1
]}

Sharon, Nir ^{[1
]}

Harlap, Susan ^{[3
]}

Friedlander, Yehiel ^{[1
]}

机构：

[1] Hadassah Hebrew Univ, Sch Publ Hlth, Jerusalem, Israel

[2] Hadassah Univ Hosp, Dept Hematol, Hadassah, Israel

[3] NYU, Dept Psychiat, New York, NY 10016 USA

来源：

LEUKEMIA RESEARCH | 2008年 / 32卷 / 11期

基金：

美国国家卫生研究院;

关键词：

birth weight; leukemia; macrosomia; intergenerational effects;

D O I：

10.1016/j.leukres.2008.04.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Although the association between birth weight and childhood leukemia is well described, the relation between a child's birth weight, and parental risk of leukemia is Unknown. We linked data from the Jerusalem Perinatal Study to the Israel Cancer Registry to ascertain the incidence of leukemia in mothers and fathers in relation to their offspring's birth weight. Birth weight >= 4500g in any of the offspring was associated with a > 3-fold risk of in mothers, but not fathers. Potential mechanisms include shared exposures of high birth weight infants and their mothers, possibly to radiation or growth factors. or genetic Pathways leading to both high birth weight and leukemia. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：1709 / 1714

页数：6

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