Synthesis and characterization of mesoporous microspherical particles for drug delivery applications

被引：0

作者：

Aggarwal, Anoop ^{[1
]}

Jolly, Sukhwinder Singh ^{[1
]}

Singh, Ravinder Pal ^{[2
,3
]}

机构：

[1] Sri Guru Granth Sahib World Univ, Dept Mech Engn, Fatehgarh Sahib, Punjab, India

[2] Lovely Profess Univ, Sch Mech Engn, Phagwara, Punjab, India

[3] Chitkara Univ, Inst Engn & Technol, Rajpura, Punjab, India

来源：

MATERIALS TODAY-PROCEEDINGS | 2020年 / 28卷

关键词：

Hydroxyapatite; Mesoporous; Morphology; Monolithic; Drug delivery; TEMPERATURE; LUMINESCENT; TIME;

D O I：

10.1016/j.matpr.2020.05.313

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Hierarchically assembled Hydroxyapatite (HAP) mesoporous particles were synthesized using a facile hydrothermal method. Products were comprehensively characterized using XRD, FTIR, FESEM and BET techniques. XRD confirmed the monolithic apatitic composition of particles. FTIR corroborated the XRD phase analysis and confirmed the carbonates structure of synthesized particles. FESEM suggested the 3D nanostructured microspherical shaped particles. The nitrogen isotherms also confirmed the formation of elongated particles with inherent mesoporous structure. The synthesized particles can be effectively employed in various multifunctional applications including drug delivery and tissue regeneration applications. (c) 2020 Elsevier Ltd. All rights reserved. Selection and peer -review under responsibility of the scientific committee of the International Confer- ence on Aspects of Materials Science and Engineering.

引用

页码：1916 / 1919

页数：4

共 10 条

[1] The resorption of nanocrystalline calcium phosphates by osteoclast-like cells [J].

Detsch, R. ;

Hagmeyer, D. ;

Neumann, M. ;

Schaefer, S. ;

Vortkamp, A. ;

Wuelling, M. ;

Ziegler, G. ;

Epple, M. .

ACTA BIOMATERIALIA, 2010, 6 (08) :3223-3233

[2] Cancer cell imaging and photothermal therapy in the near-infrared region by using gold nanorods [J].

Huang, XH ;

El-Sayed, IH ;

Qian, W ;

El-Sayed, MA .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (06) :2115-2120

[3] STUDIES OF THE SOLUBILITY OF DIFFERENT CALCIUM-PHOSPHATE CERAMIC PARTICLES INVITRO [J].

KLEIN, CPAT ;

DEBLIECKHOGERVORST, JMA ;

WOLKE, JGC ;

DEGROOT, K .

BIOMATERIALS, 1990, 11 (07) :509-512

[4] Influence of temperature and aging time on HA synthesized by the hydrothermal method [J].

Kothapalli, CR ;

Wei, M ;

Legeros, RZ ;

Shaw, MT .

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2005, 16 (05) :441-446

[5] The shape of things to come: importance of design in nanotechnology for drug delivery [J].

Liu, Yaling ;

Tan, Jifu ;

Thomas, Antony ;

Ou-Yang, Daniel ;

Muzykantov, Vladimir R. .

THERAPEUTIC DELIVERY, 2012, 3 (02) :181-194

[6] Hierarchically nanostructured mesoporous carbonated hydroxyapatite microspheres for drug delivery systems with high drug-loading capacity [J].

Long, Teng ;

Guo, Ya-Ping ;

Liu, Yi-Zhuo ;

Zhu, Zhen-An .

RSC ADVANCES, 2013, 3 (46) :24169-24176

[7] Influence of temperature, ripening time and calcination on the morphology and crystallinity of hydroxyapatite nanoparticles [J].

Pang, YX ;

Bao, X .

JOURNAL OF THE EUROPEAN CERAMIC SOCIETY, 2003, 23 (10) :1697-1704

[8] Systematic Surface Engineering of Magnetic Nanoworms for in vivo Tumor Targeting [J].

Park, Ji-Ho ;

von Maltzahn, Geoffrey ;

Zhang, Lianglin ;

Derfus, Austin M. ;

Simberg, Dmitri ;

Harris, Todd J. ;

Ruoslahti, Erkki ;

Bhatia, Sangeeta N. ;

Sailor, Michael J. .

SMALL, 2009, 5 (06) :694-700

[9] A magnetic, luminescent and mesoporous core-shell structured composite material as drug carrier [J].

Yang, Piaoping ;

Quan, Zewei ;

Hou, Zhiyao ;

Li, Chunxia ;

Kang, Xiaojiao ;

Cheng, Ziyong ;

Lin, Jun .

BIOMATERIALS, 2009, 30 (27) :4786-4795

[10] Self-activated luminescent and mesoporous strontium hydroxyapatite nanorods for drug delivery [J].

Zhang, Cuimiao ;

Li, Chunxia ;

Huang, Shanshan ;

Hou, Zhiyao ;

Cheng, Ziyong ;

Yang, Piaoping ;

Peng, Chong ;

Lin, Jun .

BIOMATERIALS, 2010, 31 (12) :3374-3383

← 1 →