Diverse Secondary Metabolites from a Lichen-Derived Amycolatopsis Strain

被引：6

作者：

Liu, Chuansheng ^{[1
]}

Jiang, Yi ^{[1
]}

Huang, Rong ^{[2
]}

Jiang, Boguang ^{[1
]}

Zheng, Kaixuan ^{[1
]}

Wu, Shaohua ^{[1
]}

机构：

[1] Yunnan Univ, Yunnan Inst Microbiol, Sch Life Sci, Kunming 650091, Yunnan, Peoples R China

[2] Yunnan Univ, Sch Chem Sci & Technol, Kunming 650091, Yunnan, Peoples R China

来源：

CURRENT MICROBIOLOGY | 2020年 / 77卷 / 09期

基金：

中国国家自然科学基金;

关键词：

NUCLEAR-MAGNETIC-RESONANCE; PHYSICOCHEMICAL PROPERTIES; MELIA-AZEDARACH; ANTIBIOTICS; FUNGUS; DIKETOPIPERAZINES; ANTIFUNGAL; IDENTIFICATION; ANTIBACTERIAL; FERMENTATION;

D O I：

10.1007/s00284-020-02049-5

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In this study, the secondary metabolites of a lichen-derived actinomycete strainAmycolatopsissp. YIM 130687 were investigated intensively by using three different media (4(#), 302(#), and 312(#)) for fermentation. A total of 21 compounds were isolated from the fermented extraction of the strain. The structures of all compounds were identified by the examination of HRESIMS and NMR spectra. Compounds1-3,5,6,21were only found in the cultivation on 302(#)medium, while compounds4,9-11were only obtained when the strain was cultured on 312(#)medium. On the other hand, compounds7,8, and20were only isolated from the fermentation product on 4(#)medium. The antimicrobial activity test showed that compound9had significant inhibitory effects on bacterial pathogens ofStaphylococcus aureusand MRSA with the MICs of 2 mu g/ml and fungal pathogens ofBotrytis cinereaandFusarium graminearumwith the MICs of 1 mu g/ml.

引用

页码：2104 / 2110

页数：7

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