Activation of the aryl hydrocarbon receptor represses mammosphere formation in MCF-7 cells

被引：41
作者：
Zhao, Shuai [1 ]
Kanno, Yuichiro [1 ]
Nakayama, Momoka [1 ]
Makimura, Minami [1 ]
Ohara, Shiori [1 ]
Inouye, Yoshio [1 ]
机构：
[1] Toho Univ, Fac Pharmaceut Sci, Chiba 2748510, Japan
来源：
CANCER LETTERS | 2012年 / 317卷 / 02期
基金：
日本学术振兴会;
关键词：
Aryl hydrocarbon receptor; Cancer stem cells; Breast cancer; STEM-CELLS; AH RECEPTOR; CANCER; MECHANISMS; EXPANSION; WNT;
D O I：
10.1016/j.canlet.2011.11.025
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor. Recent studies have reported the anti-tumor effects of the AhR in breast cancer. In this study, we investigated the anti-tumor effect of AhR activation based on the cancer stem cell hypothesis. We show that AhR activation suppressed mammosphere formation of MCF-7 cells and decreased the proportion of cells with high ALDH-1 (aldehyde dehydrogenase 1) activity. In addition, we also demonstrate that AhR activation regulates self-renewal signaling by down-regulating Wnt/beta-catenin and Notch. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：192 / 198
页数：7
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