Activation of the aryl hydrocarbon receptor represses mammosphere formation in MCF-7 cells

被引：41

作者：

Zhao, Shuai ^{[1
]}

Kanno, Yuichiro ^{[1
]}

Nakayama, Momoka ^{[1
]}

Makimura, Minami ^{[1
]}

Ohara, Shiori ^{[1
]}

Inouye, Yoshio ^{[1
]}

机构：

[1] Toho Univ, Fac Pharmaceut Sci, Chiba 2748510, Japan

来源：

CANCER LETTERS | 2012年 / 317卷 / 02期

基金：

日本学术振兴会;

关键词：

Aryl hydrocarbon receptor; Cancer stem cells; Breast cancer; STEM-CELLS; AH RECEPTOR; CANCER; MECHANISMS; EXPANSION; WNT;

D O I：

10.1016/j.canlet.2011.11.025

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor. Recent studies have reported the anti-tumor effects of the AhR in breast cancer. In this study, we investigated the anti-tumor effect of AhR activation based on the cancer stem cell hypothesis. We show that AhR activation suppressed mammosphere formation of MCF-7 cells and decreased the proportion of cells with high ALDH-1 (aldehyde dehydrogenase 1) activity. In addition, we also demonstrate that AhR activation regulates self-renewal signaling by down-regulating Wnt/beta-catenin and Notch. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

引用

页码：192 / 198

页数：7

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