High daily fraction dose external radiotherapy for T1 glottic carcinoma: Treatment results and prognostic factors

被引：17

作者：

Gultekin, Melis ^{[1
]}

Ozyar, Enis ^{[1
]}

Cengiz, Mustafa ^{[1
]}

Ozyigit, Gokhan ^{[1
]}

Hayran, Mutlu ^{[2
]}

Hosal, Sefik ^{[3
]}

Akyol, Fadil ^{[1
]}

机构：

[1] Hacettepe Univ, Fac Med, Dept Radiat Oncol, TR-06100 Ankara, Turkey

[2] Hacettepe Univ, Fac Med, Dept Prevent Oncol, TR-06100 Ankara, Turkey

[3] Hacettepe Univ, Fac Med, Dept Ear Nose & Throat Surg, TR-06100 Ankara, Turkey

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2012年 / 34卷 / 07期

关键词：

larynx; early glottic carcinoma; radiotherapy; prognostic factors; SQUAMOUS-CELL CARCINOMA; LOCAL-CONTROL; RADIATION-THERAPY; TREATMENT TIME; LARYNX; CANCER; SIZE; COMPLICATIONS; IMPACT;

D O I：

10.1002/hed.21860

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Background The purpose of this study was to investigate the prognostic factors and treatment results of T1N0M0 glottic laryngeal carcinoma irradiated with 2.3 Gray (Gy) per fraction. Methods A total of 183 patients with glottic carcinoma treated between June 1998 and January 2007 were retrospectively evaluated. Of the 183 patients, 163 patients (89%) had T1a and 20 patients (11%) had T1b disease. All patients received 2.3 Gy per fraction to a median total dose of 64.4 Gy. Results The median follow-up was 63 months. The 5-year overall survival (OS), local control, and cancer-specific survival rates were 89%, 81%, and 90%, respectively. Multivariate analysis showed overall treatment time and age to be significant prognostic factors for local control and OS. We observed no grade IV or grade V acute toxicity. Tracheaesophageal fistula as late toxicity was observed in only 1 patient. Conclusions High daily fraction scheme seems to be a feasible schedule for early glottic carcinomas. (c) 2011 Wiley Periodicals, Inc. Head Neck, 2012

引用

页码：1009 / 1014

页数：6

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