In vitro Degradation of Poly[(L-lactide)-co-(trimethylene carbonate)] Copolymers and a Composite with Poly[(L-lactide)-co-glycolide] Fibers as Cardiovascular Stent Material

被引:35
作者
Han, Yaru [2 ]
Fan, Zhongyong [2 ]
Lu, Zhiqian [1 ]
Zhang, Yong [3 ]
Li, Suming [4 ]
机构
[1] Shanghai Jiao Tong Univ, Peoples Hosp 6, Shanghai 200233, Peoples R China
[2] Fudan Univ, Dept Mat Sci, Shanghai 200433, Peoples R China
[3] Shanghai Jiao Tong Univ, Coll Chem & Chem Engn, Shanghai 200233, Peoples R China
[4] Univ Montpellier I, CNRS, UMR 5247, Max Mousseron Inst Biomol, F-34060 Montpellier, France
基金
中国国家自然科学基金;
关键词
biodegradable; composites; degradation; poly(1; 3-trimethylene carbonate); poly(L-lactide); STRUCTURE-PROPERTY RELATIONSHIPS; HYDROLYTIC DEGRADATION; 1,3-TRIMETHYLENE CARBONATE; BIODEGRADABLE POLYMERS; AQUEOUS-MEDIA; BEHAVIOR; ACIDS); VIVO;
D O I
10.1002/mame.201100113
中图分类号
T [工业技术];
学科分类号
08 ;
摘要
TMC/LLA copolymers with several TMC/LLA ratios are synthesized and a composite is obtained by reinforcing with short PLGA fibers. In vitro degradation is studied at 37 degrees C in pH=7.4 buffer and compared with a PLLA homopolymer. The degradation of the copolymers appears slower than that of PLLA, showing that TMC units are more resistant to hydrolysis than LLA. Compositional changes indicate a preferential degradation of LLA units as compared to TMC ones. Morphological changes with crystallization of degradation by-products are observed. The composite degrades much faster than the neat copolymer and PLLA because the faster degradation of PLGA fibers speeds up the degradation of the matrix. The composite appears promising for the fabrication of totally bioresorbable stents.
引用
收藏
页码:128 / 135
页数:8
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