Genetic diversity of Francisella tularensis subspecies holarctica strains isolated in Japan

被引：14

作者：

Fujita, Osamu ^{[1
]}

Uda, Akihiko ^{[1
]}

Hotta, Akitoyo ^{[1
]}

Okutani, Akiko ^{[1
]}

Inoue, Satoshi ^{[1
]}

Tanabayashi, Kiyoshi ^{[1
]}

Yamada, Akio ^{[1
]}

机构：

[1] Natl Inst Infect Dis, Deot Vet Sci, Shinjuku Ku, Tokyo 1628640, Japan

来源：

MICROBIOLOGY AND IMMUNOLOGY | 2008年 / 52卷 / 05期

关键词：

Francisella tularensis; Japan; typing; variable-number tandem repeat (VNTR);

D O I：

10.1111/j.1348-0421.2008.00036.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The recently developed MLVA has high discriminatory power for the typing of individual strains or isolates of Francisella tularensis. In the present study, MLVA was applied to 33 Japanese F. tularensis subspecies holarctica strains to examine the genetic diversity of F. tularensis isolated. Among the seven VNTR loci analyzed, Ft-M2, Ft-M10, and Ft-M20 loci showed high genetic polymorphism in Japanese strains, whereas Ft-M3 was most variable in non-Japanese strains. These results provide novel extended information about the genomic diversity among the strains of F. tularensis ssp. holarctica distributed in Japan and enable determination of whether a given isolate is indigenous to Japan by examining these loci using MLVA.

引用

页码：270 / 276

页数：7

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