Prevention of CCl4 induced adrenal oxidative stress in rat by Sonchus asper

被引：0
作者：
Khan, Rahmat Ali [1 ]
Khan, Muhammad Rashid [1 ]
Sahreen, Sumaira [1 ]
Jan, Shumaila [1 ]
Bokhari, Jasia [1 ]
Rashid, Umbreen [1 ]
机构：
[1] Quaid I Azam Univ Islamabad, Fac Biol Sci, Dept Biochem, Islamabad, Pakistan
来源：
JOURNAL OF MEDICINAL PLANTS RESEARCH | 2011年 / 5卷 / 15期
关键词：
Sonchus asper; adrenal gland; antioxidant enzymes; carbon tetrachloride; glutathione reduced (GSH); thiobarbituric acid (TBARS); CARBON-TETRACHLORIDE; PROTECTIVE ROLE; GLUTATHIONE; NEPHROTOXICITY; ENZYMES; INJURY; ASSAY;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Sonchus arvensis is used as salad, vegetable and as a human diet in Pakistan, traditionally used in the treatment of various ailments. This study was designed to investigate the mathanol extract of S. arvensis was evaluated against CCl4-induced adrenal oxidative stress in rat. The extract was administered to rats after 48 h of CCl4 treatment (3 ml/kg b.w., 30% in olive oil) twice a week for 4 weeks. CCl4 induction in rats caused reduction of antioxidant enzymes (CAT, SOD, GST, GSR, GSH-Px, and QR) while increased lipid peroxidation (TBARS) which are significantly (P<0.01) reversed by mathanol fraction of S. arvensis (CAT, SOD, GST, GSR, GSH-Px, and QR) enzymes. It is inferred that S. arvensis efficiently protects adrenal injuries induced by CCl4 in rats, possibly through antioxidant effects of bioactive compounds present in the fraction.
引用
收藏
页码：3347 / 3350
页数：4
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