Alzheimer's Aβ vaccination of rhesus monkeys (Macaca mulatta)

被引：23
作者：
Gandy, S [1 ]
DeMattos, RB
Lemere, CA
Heppner, FL
Leverone, J
Aguzzi, A
Ershler, WB
Dai, JL
Fraser, P
Hyslop, PSG
Holtzman, DM
Walker, LC
Keller, ET
机构：
[1] Thomas Jefferson Univ, Farber Inst Neurosci, Philadelphia, PA 19107 USA
[2] Washington Univ, St Louis, MO USA
[3] Harvard Univ, Inst Med, Womens Hosp Ctr Neurol Dis, Boston, MA 02115 USA
[4] Brigham Med Inst, Womens Hosp Ctr Neurol Dis, Boston, MA USA
[5] Univ Zurich, Zurich, Switzerland
[6] Inst Adv Studies Aging & Geriatr Med, Washington, DC USA
[7] Univ Michigan, Dept Lab Anim Med, Ann Arbor, MI 48109 USA
[8] Univ Toronto, Ctr Res Neurodegenerat Dis, Toronto, ON, Canada
[9] Emory Univ, Yerkes Reg Primate Res Ctr, Atlanta, GA 30322 USA
来源：
MECHANISMS OF AGEING AND DEVELOPMENT | 2004年 / 125卷 / 02期
关键词：
Alzheimers; Alzheimer's vaccination; rhesus monkey; immunization;
D O I：
10.1016/j.mad.2003.12.002
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Recent preliminary data suggest that vaccination with Alzheimer's Abeta might reduce senile plaque load and stabilize cognitive decline in human Alzheimer's disease. To examine the mechanisms and consequences of anti-Abeta-antibody formation in a species more closely related to humans, rhesus monkeys (Macaca mulatta) were vaccinated with aggregated Abeta(1-42). immunized monkeys developed anti-Abeta titers exceeding 1: 1000, and their plasma Abeta levels were 5-10-fold higher than the plasma Abeta levels observed in monkeys vaccinated with aggregated amylin. These data support the use of non-human primates to model certain phenomena associated with vaccination of humans with aggregated Alzheimer's Abeta. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：149 / 151
页数：3
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