In Vitro Antibacterial Activity of the Ceftazidime-Avibactam (NXL104) Combination against Pseudomonas aeruginosa Clinical Isolates

被引：93
|
作者：
Levasseur, Premavathy [1 ]
Girard, Anne-Marie [1 ]
Claudon, Monique [1 ]
Goossens, Herman [2 ]
Black, Michael T. [1 ]
Coleman, Kenneth [1 ]
Miossec, Christine [1 ]
机构：
[1] Novexel SA, Romainville, France
[2] Univ Antwerp Hosp, Vaccine & Infect Dis Inst, Dept Microbiol, Edegem, Belgium
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2012年 / 56卷 / 03期
关键词：
D O I：
10.1128/AAC.06064-11
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The beta-lactamase inhibitor avibactam (NXL104) displays potent inhibition of both class A and C enzymes. The in vitro antibacterial activity of the combination ceftazidime-avibactam was evaluated against a clinical panel of Pseudomonas aeruginosa isolates. Avibactam offered efficient protection from hydrolysis since 94% of isolates were susceptible to ceftazidime when combined with 4 mu g/ml avibactam, compared with 65% susceptible to ceftazidime alone. Ceftazidime-avibactam also demonstrated better antipseudomonal activity than imipenem (82% susceptibility), a common reference treatment.
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收藏
页码：1606 / 1608
页数：3
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