Piper regnellii extract biopolymer-based microparticles: production, characterization and antifungal activity

被引:2
|
作者
Brambilla, L. Z. S. [1 ]
Endo, E. H. [1 ]
Cortez, D. A. G. [2 ]
Lima, M. M. S. [2 ]
Dias Filho, B. P. [2 ]
机构
[1] Univ Estadual Maringa, Post Grad Program Pharmaceut Sci, Maringa, Parana, Brazil
[2] Univ Estadual Maringa, Dept Pharm, Ave Colombo 5790,Bloco B-08, BR-87020900 Maringa, Parana, Brazil
关键词
antifungal; dichloromethane extract; microparticles; Piper regnellii; spray drying; Trichophyton rubrum; C.-DC; YUNCK; VAR; PALLESCENS; CONTROLLED-RELEASE; NEOLIGNANS; GELATIN; DERMATOPHYTES; ENCAPSULATION; DELIVERY; SYSTEM; FILMS;
D O I
10.1111/jam.13618
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Aims: This study aims to improve characteristics of Piper regnellii extract to make it applicable in formulations to treat dermatophytosis, also known as ringworm. Methods and Results: Microparticles (MPs) were produced by spray drying with gelatin, alginate and chitosan as encapsulating agents; characterized by scanning electron microscopy, encapsulation efficiency, thermal analyses and X-ray diffraction; and tested against Trichophyton rubrum by broth microdilution. Produced MPs had a mean diameter less than 2 lm, an increase in stability and release of the extract and good results for encapsulation efficiency, being 85.6% to gelatin MP, 71.3% to chitosan MP and 60.6% to alginate. MPs preserved the antifungal activity of P. regnellii extract T. rubrum. Conclusion: Microencapsulation provided a significant improvement in the stability of the P. regnellii extract and better solubilization of chemical compounds, maintaining the antifungal effect against T. rubrum. Significance and Impact of the Study: These results are useful for developing a formulation to treat fungal infections caused by dermatophyte species.
引用
收藏
页码:75 / 84
页数:10
相关论文
共 50 条
  • [1] Biopolymer-based nanoparticles and microparticles: Fabrication, characterization, and application
    Joye, Iris Julie
    McClements, David Julian
    CURRENT OPINION IN COLLOID & INTERFACE SCIENCE, 2014, 19 (05) : 417 - 427
  • [2] Enhancing the Antifungal Activity of Griseofulvin by Incorporation a Green Biopolymer-Based Nanocomposite
    Shehabeldine, Amr
    El-Hamshary, Hany
    Hasanin, Mohamed
    El-Faham, Ayman
    Al-Sahly, Mosaed
    POLYMERS, 2021, 13 (04) : 1 - 12
  • [3] Biopolymer-Based Multilayer Microparticles for Probiotic Delivery to Colon
    Talebian, Sepehr
    Schofield, Timothy
    Valtchev, Peter
    Schindeler, Aaron
    Kavanagh, John M.
    Adil, Qayyum
    Dehghani, Fariba
    ADVANCED HEALTHCARE MATERIALS, 2022, 11 (11)
  • [4] Evaluation of antifungal activity of extracts of Piper regnellii obtained by supercritical fluid extraction
    Terra Lemos, Caroline Ortega
    Estivalet Svidzinsk, Terezinha Inez
    Baeza, Lilian Cristiane
    Miranda, Nathielle
    Nakamura, Celso Vataru
    Garcia Cortez, Diogenes Aparicio
    Cardozo-Filho, Lucio
    Cabral, Vladimir Ferreira
    NATURAL PRODUCT RESEARCH, 2013, 27 (24) : 2355 - 2359
  • [5] In vitro antifungal activity of extracts and neolignans from Piper regnellii against dermatophytes
    Koroishi, Andrea M.
    Foss, Simone R.
    Cortez, Diogenes A. G.
    Ueda-Nakamura, Tania
    Nakamurad, Celso Vataru
    Dias Filho, Benedito P.
    JOURNAL OF ETHNOPHARMACOLOGY, 2008, 117 (02) : 270 - 277
  • [6] Biopolymer-based coating materials for antiviral and antifungal applications: Recent advances in formulations and characterization
    Juthi, Zarin Tasnim
    Jabeen, Mahe
    Islam, Md Reazul
    Biswas, Payel
    Ahmed, Shoeb
    CHEMICAL ENGINEERING JOURNAL, 2024, 498
  • [7] Biopolymer-Based Nanofiber Mats and Their Mechanical Characterization
    Khansari, Shahrzad
    Sinha-Ray, Suman
    Yarin, Alexander L.
    Pourdeyhimi, Behnam
    INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 2013, 52 (43) : 15104 - 15113
  • [8] Biopolymer-based microparticles for encapsulation of all-trans-retinoic acid
    Silva, Leticia A.
    Dambros, Roberta
    Leonardi, Gislaine R.
    Perrechil, Fabiana
    JOURNAL OF APPLIED POLYMER SCIENCE, 2021, 138 (45)
  • [9] Deep Eutectic Solvents in the Production of Biopolymer-Based Materials
    Loncaric, Melita
    Jakobek, Lidija
    Molnar, Maja
    CROATICA CHEMICA ACTA, 2021, 94 (02)
  • [10] Synthesis and characterization of biopolymer-based copper carbonate nanoparticles
    Blinov, Andrey
    Yasnaya, Mariya
    Gvozdenko, Alexey
    Rekhman, Zafar
    Filippov, Dionis
    Golik, Alexey
    Askerova, Alina
    Bocharov, Nikita
    Nagdalian, Andrey
    MATERIALS TODAY COMMUNICATIONS, 2025, 42