Cytokines and their effects on maturation, differentiation and migration of dendritic cells

被引：90
|
作者：
Jonuleit, H
Knop, J
Enk, AH
机构：
[1] Department of Dermatology, University of Mainz, D-55131 Mainz
来源：
ARCHIVES OF DERMATOLOGICAL RESEARCH | 1996年 / 289卷 / 01期
关键词：
dendritic cell; Langerhans cell; cytokines; dendritic cell differentiation;
D O I：
10.1007/s004030050144
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
In this review the role of cytokines in the maturation and migration of phenotypically and functionally diverse dendritic cell (DC) subpopulations is discussed and their role in the progress of differentiation from bone marrow progenitors to lymphoid DC is described. GM-CSF is the most important cytokine for the development of functional DC and acts in concert with a varying mixture of other cytokines such as IL-4, IL-1 and TNF-alpha to direct the development of individual DC subpopulations.
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页码：1 / 8
页数：8
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