Binding of lactoferrin and free secretory component to enterotoxigenic Escherichia coli

被引：59
作者：
de Oliveira, IR
de Araújo, AN
Bao, SN
Giugliano, LG [1 ]
机构：
[1] Univ Brasilia, Inst Biol, Dept Biol Celular, Microbiol Lab, BR-70910900 Brasilia, DF, Brazil
[2] Univ Brasilia, Inst Biol, Dept Biol Celular, Lab Microscopia Eletr, BR-70910900 Brasilia, DF, Brazil
来源：
FEMS MICROBIOLOGY LETTERS | 2001年 / 203卷 / 01期
关键词：
diarrhea; human milk; lactoferrin; free secretory component; colonization factor antigen; enterotoxigenic Escherichia coli;
D O I：
10.1016/S0378-1097(01)00332-9
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The ability of two glycoproteins of human milk, lactoferrin and free secretory component, to bind to Escherichia coli colonization factors (CFAs) was investigated using immunocytochemistry assays of enriched fimbrial extracts. The results revealed that lactoferrin binds to fimbrial CFA I adhesin but not to CFA II adhesin (CS1 and CS3), while free secretory component interacts with both CFA I and CFA II adhesins. Our data indicate that lactoferrin and free secretory component, which are very abundant proteins of human milk, could play an important role against infant enteric disease by blocking bacterial adhesion. (C) 2001 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.
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页码：29 / 33
页数：5
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