Modular synthesis of mono, di, and tri-1,4-disubstituted-1,2,3-triazoles through copper-mediated alkyne-azide cycloaddition

被引：24

作者：

Stefani, Helio A. ^{[1
]}

Canduzini, Hugo A. ^{[1
]}

Manarin, Flavia ^{[1
]}

机构：

[1] Univ Sao Paulo, Dept Farm, Fac Ciencias Farmaceut, BR-05508 Sao Paulo, Brazil

来源：

TETRAHEDRON LETTERS | 2011年 / 52卷 / 46期

基金：

巴西圣保罗研究基金会;

关键词：

Click chemistry; 1,2,3-Triazole; Cycloaddition; Propargyl alcohol; Ultrasound; CLICK-CHEMISTRY; ANTIMICROBIAL ACTIVITY; TERMINAL ALKYNES; WATER; ACID;

D O I：

10.1016/j.tetlet.2011.09.004

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of 1,2,3-triazoles was developed employing sequential copper azide-alkyne cycloaddition, tosylation, sodium azide, and copper azide-alkyne steps. This approach allowed the synthesis of two and three 1,2,3-triazole rings. A preliminary study to gain further insight into the reaction was performed using in situ ReactIR technology. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：6086 / 6090

页数：5

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