Biological performance of hydroxyapatite-biopolymer foams: In vitro cell response

被引：24

作者：

Cicuendez, Monica

Izquierdo-Barba, Isabel

Sanchez-Salcedo, Sandra

Vila, Mercedes

Vallet-Regi, Maria ^{[1
]}

机构：

[1] Univ Complutense Madrid, Fac Farm, Dept Quim Inorgan & Bioinorgan, E-28040 Madrid, Spain

来源：

ACTA BIOMATERIALIA | 2012年 / 8卷 / 02期

关键词：

Macroporous foam; Hydroxyapatite; In vitro cell response; Scaffolds; Biopolymer coating; CALCIUM-PHOSPHATE SCAFFOLDS; BIOACTIVE GLASS; TISSUE; BIOCOMPATIBILITY; OSTEOBLASTS; CULTURE; FIBROBLASTS;

D O I：

10.1016/j.actbio.2011.09.019

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Uncoated and biopolymer-coated nanocrystalline hydroxyapatite (HA) macroporous foams are presented as promising candidates as scaffolds for bone tissue regeneration. To this end, foam degradability, the cytotoxic effects on osteoblast-like cells of foam degradation by-products and biocompatibility with osteoblast-like cells were assayed on the three-dimensional (3-D) foam surface. The results show that the 3-D interconnected architectural design of these HA foams allows excellent osteoblast internalization, proliferation and differentiation, exhibiting adequate colonization over the entire scaffold surface with an appropriate degradation rate without any cytotoxic effects. (C) 2011 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

引用

页码：802 / 810

页数：9

共 35 条

[1] Interaction of an ordered mesoporous bioactive glass with osteoblasts, fibroblasts and lymphocytes, demonstrating its biocompatibility as a potential bone graft material [J].