HCO3- secretion by bullfrog duodenum:: dependence on nutrient Na+ during secretory stimulation

被引:7
|
作者
Goddard, PJ
Takahashi, S
Milbank, AJ
Silen, W
Soybel, DI
机构
[1] Harvard Univ, Sch Med, Beth Israel Hosp, Dept Surg, Boston, MA 02115 USA
[2] Harvard Univ, Ctr Digest Dis, Boston, MA 02115 USA
[3] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Surg, Boston, MA 02115 USA
关键词
duodenum; duodenal mucosa; bicarbonate ion; ion transport; amphibian; acetazolamide; sodium-bicarbonate cotransport; chloride-bicarbonate exchange;
D O I
10.1139/cjpp-76-9-882
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
HCO3- secretion across in vitro duodenal mucosa of Rana catesbeiana was investigated under baseline conditions and during secretory stimulation. Baseline secretion was abolished by removal of CO2-HCO3- and reduced similar to 60% by removal of nutrient Na+, but was not sensitive to changes in Cl- or K+. Baseline secretion was not directly altered by exposure to 10(-3) M amiloride or 10(-3) M H2DIDS (dihydro-4,4'-diisothiocyanostilbene-2,2'-disulfonic acid) in the nutrient solution and only mildly reduced by acetazolamide. Following removal and restoration of Na+, recovery of secretion was impaired by exposure to acetazolamide (5 x 10(-4) M) or H2DIDS (5 x 10(-4) M) in the nutrient solution. Secretion stimulated by glucagon (10(-4) M) or 16,16-dimethyl prostaglandin E-2 (10 mu g mL(-1)) was markedly attenuated by removal of Na+ or by exposure to H2DIDS but secretion was not altered by acetazolamide (5 x 10(-4) M) or nutrient amiloride (1 mM). Thus, the HCO3- that is secreted under nonstimulated conditions derives partly from basolateral Na+-dependent uptake and partly from cellular CO2 hydration. Secretagogue-stimulated secretion by duodenal surface epithelium depends on stilbene-sensitive Na+(HCO3-)(n) uptake across the basolateral membrane.
引用
收藏
页码:882 / 890
页数:9
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