Serial proton spectroscopy in a case of adult-onset subacute sclerosing panencephalitis

被引：2
作者：
Michael, N
Erfurth, A
Lüdemann, P
Schuierer, G
Möller, HE
机构：
[1] Max Planck Inst Human Cognit & Brain Sci, D-04103 Leipzig, Germany
[2] Univ Munster, Dept Psychiat, D-48129 Munster, Germany
[3] Univ Munster, Dept Neurol, D-48129 Munster, Germany
[4] Univ Regensburg, Inst Neuroradiol, District Med Ctr, D-93053 Regensburg, Germany
[5] Univ Munster, Dept Radiol, D-48129 Munster, Germany
来源：
PSYCHIATRY RESEARCH-NEUROIMAGING | 2005年 / 139卷 / 03期
关键词：
electroconvulsive therapy; interferon-alpha; proton magnetic resonance spectroscopy; psychosis; subacute sclerosing panencephalitis;
D O I：
10.1016/j.pscychresns.2005.01.003
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
A case of subacute sclerosing partencephalitis in a 27-year-old man was serially evaluated with proton magnetic resonance spectroscopy. Metabolic abnormalities included decreased N-acetylaspartate and elevated choline and myo-inositol in a lesion visible on magnetic resonance imaging and in normal-appearing white matter. Lactate appeared increased within the lesion. Metabolic impairment was persistent after intrathecal interferon-a treatment. Spectroscopy pointing to ongoing inflammation, gliosis, and possible membrane turnover was more sensitive than imaging in detecting widespread pathology within the white matter. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：269 / 273
页数：5
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