Reduced Titers of Circulating Anti-SARS-CoV-2 Antibodies and Risk of COVID-19 Infection in Healthcare Workers during the Nine Months after Immunization with the BNT162b2 mRNA Vaccine

被引:38
作者
Coppeta, Luca [1 ]
Ferrari, Cristiana [1 ]
Somma, Giuseppina [1 ]
Mazza, Andrea [1 ]
D'Ancona, Umberto [1 ]
Marcuccilli, Fabbio [2 ]
Grelli, Sandro [2 ]
Aurilio, Marco Trabucco [3 ]
Pietroiusti, Antonio [4 ]
Magrini, Andrea [1 ]
Rizza, Stefano [5 ]
机构
[1] Univ Roma Tor Vergata, Dept Occupat Med, I-00133 Rome, Italy
[2] Univ Roma Tor Vergata, Dept Expt Med, I-00133 Rome, Italy
[3] Univ Molise, Dept Med & Hlth Sci Tiberio, I-86100 Campobasso, Italy
[4] Univ Unicamillus, Dept Fac Med, I-00131 Rome, Italy
[5] Univ Roma Tor Vergata, Dept Syst Med, Viale Oxford 81, I-00133 Rome, Italy
关键词
COVID-19; SARS-CoV-2; healthcare workers; vaccine; BNT162b2 mRNA vaccine; anti-S-RBD antibodies; SARS-COV-2; IMMUNITY;
D O I
10.3390/vaccines10020141
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has had a tremendous impact on health services; hundreds of thousands of healthcare workers (HCWs) have died from coronavirus disease 2019 (COVID-19). The introduction of the BNT162b2 mRNA vaccine in Italy provided recipients with significant protection against COVID-19 within one to two weeks after the administration of the second of the two recommended doses. While the vaccine induces a robust T cell response, the protective role of factors and pathways other than those related to memory B cell responses to specific SARS-CoV-2 antigens remains unclear. This retrospective study aimed to evaluate the determinants of serological protection in a group of vaccinated HCWs (n = 793) by evaluating circulating levels of antiviral spike receptor-binding domain (S-RBD) antibodies during the nine-month period following vaccination. We found that 99.5% of the HCWs who received the two doses of the BNT162b2 vaccine developed protective antibodies that were maintained at detectable levels for as long as 250 days after the second dose of the vaccine. Multivariate analysis was performed on anti-S-RBD titers in a subgroup of participants (n = 173) that were evaluated twice during this period. The results of this analysis reveal that the antibody titer observed at the second time point was significantly related to the magnitude of the primary response, the time that had elapsed between the first and the second evaluation, and a previous history of SARS-CoV-2 infection. Of importance is the finding that despite waning antibody titers following vaccination, none of the study participants contracted severe COVID-19 during the observational period.
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共 35 条
[1]   Sleep disorders and COVID-19 [J].
Bhat, Sushanth ;
Chokroverty, Sudhansu .
SLEEP MEDICINE, 2022, 91 :253-261
[2]   Dynamics of SARS-CoV-2 neutralising antibody responses and duration of immunity: a longitudinal study [J].
Chia, Wan Ni ;
Zhu, Feng ;
Ong, Sean Wei Xiang ;
Young, Barnaby Edward ;
Fong, Siew-Wai ;
Le Bert, Nina ;
Tan, Chee Wah ;
Tiu, Charles ;
Zhang, Jinyan ;
Tan, Seow Yen ;
Pada, Surinder ;
Chan, Yi-Hao ;
Tham, Christine Y. L. ;
Kunasegaran, Kamini ;
Chen, Mark I-C ;
Low, Jenny G. H. ;
Leo, Yee-Sin ;
Renia, Laurent ;
Bertoletti, Antonio ;
Ng, Lisa F. P. ;
Lye, David Chien ;
Wang, Lin-Fa .
LANCET MICROBE, 2021, 2 (06) :E240-E249
[3]   Antibody Responses in COVID-19: A Review [J].
Chvatal-Medina, Mateo ;
Mendez-Cortina, Yorjagis ;
Patino, Pablo J. ;
Velilla, Paula A. ;
Rugeles, Maria T. .
FRONTIERS IN IMMUNOLOGY, 2021, 12
[4]   First Dose of the BNT162b2 mRNA COVID-19 Vaccine Reduces Symptom Duration and Viral Clearance in Healthcare Workers [J].
Coppeta, Luca ;
Balbi, Ottavia ;
Grattagliano, Zaira ;
Mina, Grazia Genga ;
Pietroiusti, Antonio ;
Magrini, Andrea ;
Bolcato, Matteo ;
Trabucco Aurilio, Marco .
VACCINES, 2021, 9 (06)
[5]   Contact Screening for Healthcare Workers Exposed to Patients with COVID-19 [J].
Coppeta, Luca ;
Somma, Giuseppina ;
Ippoliti, Lorenzo ;
Ferrari, Cristiana ;
D'Alessandro, Iacopo ;
Pietroiusti, Antonio ;
Trabucco Aurilio, Marco .
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 2020, 17 (23) :1-7
[6]   Persistence of Immunity for Hepatitis B Virus among Heathcare Workers and Italian Medical Students 20 Years after Vaccination [J].
Coppeta, Luca ;
Pompei, Andrea ;
Balbi, Ottavia ;
De Zordo, Ludovico M. ;
Mormone, Federica ;
Policardo, Sara ;
Lieto, Piergiorgio ;
Pietroiusti, Antonio ;
Magrini, Andrea .
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 2019, 16 (09)
[7]   Prospects for durable immune control of SARS-CoV-2 and prevention of reinfection [J].
Cromer, Deborah ;
Juno, Jennifer A. ;
Khoury, David ;
Reynaldi, Arnold ;
Wheatley, Adam K. ;
Kent, Stephen J. ;
Davenport, Miles P. .
NATURE REVIEWS IMMUNOLOGY, 2021, 21 (06) :395-404
[8]  
Dalle Carbonare L, 2021, COMMUNITY MED, V1, P38, DOI DOI 10.1038/S43856-021-00039-7
[9]   COVID vaccine immunity is waning - how much does that matter? [J].
Dolgin, Elie .
NATURE, 2021, 597 (7878) :606-607
[10]   Antibody Persistence through 6 Months after the Second Dose of mRNA-1273 Vaccine for Covid-19 [J].
Doria-Rose, Nicole ;
Suthar, Mehul S. ;
Makowski, Mat .
NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (23) :2259-2261