Reduced Titers of Circulating Anti-SARS-CoV-2 Antibodies and Risk of COVID-19 Infection in Healthcare Workers during the Nine Months after Immunization with the BNT162b2 mRNA Vaccine
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作者:
Coppeta, Luca
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Univ Roma Tor Vergata, Dept Occupat Med, I-00133 Rome, ItalyUniv Roma Tor Vergata, Dept Occupat Med, I-00133 Rome, Italy
Coppeta, Luca
[1
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Ferrari, Cristiana
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Univ Roma Tor Vergata, Dept Occupat Med, I-00133 Rome, ItalyUniv Roma Tor Vergata, Dept Occupat Med, I-00133 Rome, Italy
Ferrari, Cristiana
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Somma, Giuseppina
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Univ Roma Tor Vergata, Dept Occupat Med, I-00133 Rome, ItalyUniv Roma Tor Vergata, Dept Occupat Med, I-00133 Rome, Italy
Somma, Giuseppina
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Mazza, Andrea
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Univ Roma Tor Vergata, Dept Occupat Med, I-00133 Rome, ItalyUniv Roma Tor Vergata, Dept Occupat Med, I-00133 Rome, Italy
Mazza, Andrea
[1
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D'Ancona, Umberto
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Univ Roma Tor Vergata, Dept Occupat Med, I-00133 Rome, ItalyUniv Roma Tor Vergata, Dept Occupat Med, I-00133 Rome, Italy
D'Ancona, Umberto
[1
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Marcuccilli, Fabbio
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Univ Roma Tor Vergata, Dept Expt Med, I-00133 Rome, ItalyUniv Roma Tor Vergata, Dept Occupat Med, I-00133 Rome, Italy
Marcuccilli, Fabbio
[2
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Grelli, Sandro
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Univ Roma Tor Vergata, Dept Expt Med, I-00133 Rome, ItalyUniv Roma Tor Vergata, Dept Occupat Med, I-00133 Rome, Italy
Grelli, Sandro
[2
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Aurilio, Marco Trabucco
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Univ Molise, Dept Med & Hlth Sci Tiberio, I-86100 Campobasso, ItalyUniv Roma Tor Vergata, Dept Occupat Med, I-00133 Rome, Italy
Aurilio, Marco Trabucco
[3
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Pietroiusti, Antonio
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Univ Unicamillus, Dept Fac Med, I-00131 Rome, ItalyUniv Roma Tor Vergata, Dept Occupat Med, I-00133 Rome, Italy
Pietroiusti, Antonio
[4
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Magrini, Andrea
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Univ Roma Tor Vergata, Dept Occupat Med, I-00133 Rome, ItalyUniv Roma Tor Vergata, Dept Occupat Med, I-00133 Rome, Italy
Magrini, Andrea
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Rizza, Stefano
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Univ Roma Tor Vergata, Dept Syst Med, Viale Oxford 81, I-00133 Rome, ItalyUniv Roma Tor Vergata, Dept Occupat Med, I-00133 Rome, Italy
Rizza, Stefano
[5
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机构:
[1] Univ Roma Tor Vergata, Dept Occupat Med, I-00133 Rome, Italy
[2] Univ Roma Tor Vergata, Dept Expt Med, I-00133 Rome, Italy
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has had a tremendous impact on health services; hundreds of thousands of healthcare workers (HCWs) have died from coronavirus disease 2019 (COVID-19). The introduction of the BNT162b2 mRNA vaccine in Italy provided recipients with significant protection against COVID-19 within one to two weeks after the administration of the second of the two recommended doses. While the vaccine induces a robust T cell response, the protective role of factors and pathways other than those related to memory B cell responses to specific SARS-CoV-2 antigens remains unclear. This retrospective study aimed to evaluate the determinants of serological protection in a group of vaccinated HCWs (n = 793) by evaluating circulating levels of antiviral spike receptor-binding domain (S-RBD) antibodies during the nine-month period following vaccination. We found that 99.5% of the HCWs who received the two doses of the BNT162b2 vaccine developed protective antibodies that were maintained at detectable levels for as long as 250 days after the second dose of the vaccine. Multivariate analysis was performed on anti-S-RBD titers in a subgroup of participants (n = 173) that were evaluated twice during this period. The results of this analysis reveal that the antibody titer observed at the second time point was significantly related to the magnitude of the primary response, the time that had elapsed between the first and the second evaluation, and a previous history of SARS-CoV-2 infection. Of importance is the finding that despite waning antibody titers following vaccination, none of the study participants contracted severe COVID-19 during the observational period.
机构:
Hackensack Meridian Hlth JFK Univ Med Ctr, 65 James St, Edison, NJ 08818 USAHackensack Meridian Hlth JFK Univ Med Ctr, 65 James St, Edison, NJ 08818 USA
Bhat, Sushanth
;
Chokroverty, Sudhansu
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机构:
Hackensack Meridian Hlth JFK Univ Med Ctr, Sleep Med Res, 65 James St, Edison, NJ 08818 USA
Hackensack Meridian Hlth JFK Univ Med Ctr, Neurol, 65 James St, Edison, NJ 08818 USAHackensack Meridian Hlth JFK Univ Med Ctr, 65 James St, Edison, NJ 08818 USA
机构:
Hackensack Meridian Hlth JFK Univ Med Ctr, 65 James St, Edison, NJ 08818 USAHackensack Meridian Hlth JFK Univ Med Ctr, 65 James St, Edison, NJ 08818 USA
Bhat, Sushanth
;
Chokroverty, Sudhansu
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机构:
Hackensack Meridian Hlth JFK Univ Med Ctr, Sleep Med Res, 65 James St, Edison, NJ 08818 USA
Hackensack Meridian Hlth JFK Univ Med Ctr, Neurol, 65 James St, Edison, NJ 08818 USAHackensack Meridian Hlth JFK Univ Med Ctr, 65 James St, Edison, NJ 08818 USA