Long-range interaction between the P2.1 and P9.1 peripheral domains of the tetrahymena ribozyme

被引：16

作者：

Ikawa, Y ^{[1
]}

Ohta, H ^{[1
]}

Shiraishi, H ^{[1
]}

Inoue, T ^{[1
]}

机构：

[1] KYOTO UNIV,FAC SCI,DEPT CHEM,KYOTO 60601,JAPAN

来源：

NUCLEIC ACIDS RESEARCH | 1997年 / 25卷 / 09期

关键词：

D O I：

10.1093/nar/25.9.1761

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Tetrahymena ribozyme possesses peripheral domains, termed P9.1 and P9.2. They are nonessential in the mechanism of the catalytic reaction but contribute to enhance the catalytic activity of the ribozyme. It has been postulated that P9.1 is capable of forming Watson-Crick base pairings with another peripheral domain, P2.1. We report hem the existence of long-range base pairings between the loop regions of these two domains and show that this interaction apparently plays a role in enhancing the catalytic activity of the ribozyme.

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页码：1761 / 1765

页数：5

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