Frailty and Delayed Graft Function in Kidney Transplant Recipients

被引：183

作者：

Garonzik-Wang, Jacqueline M. ^{[1
]}

Govindan, Priyanka ^{[1
]}

Grinnan, Jack W. ^{[1
]}

Liu, Minghao ^{[1
]}

Ali, Hassan M. ^{[1
]}

Chakraborty, Anindita ^{[1
]}

Jain, Vaibhav ^{[1
]}

Ros, Reside L. ^{[1
]}

James, Nathan T. ^{[1
]}

Kucirka, Lauren M. ^{[1
]}

Hall, Erin C. ^{[1
,3
]}

Berger, Jonathan C. ^{[1
]}

Montgomery, Robert A. ^{[1
]}

Desai, Niraj M. ^{[1
]}

Dagher, Nabil N. ^{[1
]}

Sonnenday, Christopher J. ^{[4
,5
]}

Englesbe, Michael J. ^{[4
]}

Makary, Martin A. ^{[1
]}

Walston, Jeremy D. ^{[1
]}

Segev, Dorry L. ^{[1
,2
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Surg, Baltimore, MD 21205 USA

[2] Johns Hopkins Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA

[3] Georgetown Univ, Dept Surg, Washington, DC USA

[4] Univ Michigan Hlth Syst, Dept Surg, Ann Arbor, MI USA

[5] Univ Michigan, Sch Publ Hlth, Dept Hlth Management & Policy, Ann Arbor, MI 48109 USA

来源：

ARCHIVES OF SURGERY | 2012年 / 147卷 / 02期

关键词：

OLDER-ADULTS; INFLAMMATION; COMORBIDITIES; PHENOTYPE; OUTCOMES; HEALTH;

D O I：

10.1001/archsurg.2011.1229

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

The ability to predict outcomes following a kidney transplant is limited by the complex physiologic decline of kidney failure, a latent factor that is difficult to capture using conventional comorbidity assessment. The frailty phenotype is a recently described inflammatory state of increased vulnerability to stressors resulting from decreased physiologic reserve and dysregulation of multiple physiologic systems. We hypothesized that frailty would be associated with delayed graft function, based on putative associations between inflammatory cytokines and graft dysfunction. We prospectively measured frailty in 183 kidney transplant recipients between December 2008 andApril 2010. Independent associations between frailty and delayed graft function were analyzed using modified Poisson regression. Preoperative frailty was independently associated with a 1.94-fold increased risk for delayed graft function (95% CI, 1.13-3.36; P=.02). The assessment of frailty may provide further insights into the pathophysiology of allograft dysfunction and may improve our ability to preoperatively risk-stratify kidney transplant recipients. Arch Surg. 2012;147(2):190-193

引用

页码：190 / 193

页数：4

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