Amorphization of drugs by adsorptive precipitation from supercritical solutions: A review

被引：77
作者：
Gurikov, Pavel [1 ]
Smirnova, Irina [1 ]
机构：
[1] Hamburg Univ Technol, Inst Thermal Separat Proc, Eissendorfer Str 38, D-21073 Hamburg, Germany
来源：
JOURNAL OF SUPERCRITICAL FLUIDS | 2018年 / 132卷
关键词：
Precipitation; Adsorption; Amorphization; Supercritical carbon dioxide; Drug delivery systems; LIQUID-GAS EQUILIBRIUM; MCM-41 MESOPOROUS SILICA; WATER-SOLUBLE DRUG; RESS-SC PROCESS; CARBON-DIOXIDE; RAPID EXPANSION; AEROGEL MICROSPHERES; ORAL BIOAVAILABILITY; DISSOLUTION RATE; DIFFUSION-COEFFICIENTS;
D O I：
10.1016/j.supflu.2017.03.005
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
In this review, available experimental data on the drug confinement in porous matrices via adsorptive precipitation from supercritical fluid solutions with a special emphasis on the drug amorphization is provided. Practical aspects and opportunities for the process optimization are discussed in view of thermodynamic considerations. An attempt is made to elaborate a simplified model that takes into account drug drug and drug matrix interactions with the aim of rationalizing the experimental outcomes with respect to the physical state of the confined drug. Potential points of growth and some bottlenecks of the adsorptive precipitation from supercritical solutions are outlined. (C) 2017 Elsevier B.V. All rights reserved.
引用
收藏
页码：105 / 125
页数：21
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