Common Variants in the Periostin Gene Influence Development of Atherosclerosis in Young Persons

被引：27

作者：

Hixson, James E. ^{[1
]}

Shimmin, Lawrence C. ^{[1
]}

Montasser, May E. ^{[1
]}

Kim, Do-Kyun ^{[1
]}

Zhong, Yu ^{[1
]}

Ibarguen, Heladio ^{[1
]}

Follis, Jack ^{[1
]}

Malcom, Gray ^{[2
]}

Strong, Jack ^{[2
]}

Howard, Tim ^{[3
]}

Langefeld, Carl ^{[4
]}

Liu, Yongmei ^{[5
]}

Rotter, Jerome I. ^{[7
]}

Johnson, Craig ^{[8
]}

Herrington, David ^{[6
]}

机构：

[1] Univ Texas Hlth Sci Ctr Houston, Ctr Human Genet, Houston, TX USA

[2] Louisiana State Univ, Hlth Sci Ctr, Dept Pathol, New Orleans, LA USA

[3] Wake Forest Univ, Bowman Gray Sch Med, Ctr Human Genom, Winston Salem, NC USA

[4] Wake Forest Univ, Bowman Gray Sch Med, Sect Stat Genet & Bioinformat, Winston Salem, NC USA

[5] Wake Forest Univ, Bowman Gray Sch Med, Div Publ Hlth Sci, Winston Salem, NC USA

[6] Wake Forest Univ, Bowman Gray Sch Med, Dept Internal Med Cardiol, Winston Salem, NC USA

[7] Cedars Sinai Med Ctr, Inst Med Genet, Los Angeles, CA 90048 USA

[8] Univ Washington, Collaborat Hlth Studies Coordinating Ctr, Seattle, WA 98195 USA

来源：

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | 2011年 / 31卷 / 07期

基金：

美国国家卫生研究院;

关键词：

atherosclerosis; epidemiology; gene mutations; risk factors; ASSOCIATION; POLYMORPHISMS; EXPRESSION;

D O I：

10.1161/ATVBAHA.111.224352

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective-We investigated the influence of genetic variants (rare and common) in the gene encoding periostin (POSTN) on atherosclerosis as measured in arterial specimens from the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) study. Methods and Results-A comprehensive survey of common POSTN variants (87 single-nucleotide polymorphisms [SNPs]) in PDAY subjects (n=2527) identified numerous SNPs associated with raised lesions in abdominal aorta and with fatty streaks in thoracic aorta. These SNPs belonged to a small number of correlation bins that spanned the entire locus. To examine effects of rare variants, we resequenced POSTN functional regions in PDAY cases with raised lesions (n=291) and controls with no raised lesions (n=294). However, we found no significant associations with case-control status for carriers of POSTN rare variants using the weighted-sum method for rare variant analysis. Conclusion-We identified common variants in POSTN that are associated with arterial lesions in young persons from the PDAY study. This finding strongly supports a role for periostin in atherogenesis, as suggested by recent proteomics analysis that found abundant expression of periostin in atherosclerotic lesions. Genetic variation may influence atherosclerosis via periostin's known involvement in multiple relevant pathways, including angiogenesis, vascular remodeling, and stimulation of migration and differentiation of vascular smooth muscle cells. (Arterioscler Thromb Vasc Biol. 2011; 31: 1661-1667.)

引用

页码：1661 / U430

页数：17

共 17 条

[11] Vascular injury induces expression of periostin - Implications for vascular cell differentiation and migration [J].

Lindner, V ;

Wang, QZ ;

Conley, BA ;

Friesel, RE ;

Vary, CPH .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2005, 25 (01) :77-83

[12] Identification and characterization of a novel Schwann and outflow tract endocardial cushion lineage-restricted periostin enhancer [J].

Lindsley, Andrew ;

Snider, Paige ;

Zhou, Hongming ;

Rogers, Rhonda ;

Wang, Jian ;

Olaopa, Michael ;

Kruzynska-Frejtag, Agnieszka ;

Koushik, Shrinagesh V. ;

Lilly, Brenda ;

Burch, John B. E. ;

Firulli, Anthony B. ;

Conway, Simon J. .

DEVELOPMENTAL BIOLOGY, 2007, 307 (02) :340-355

[13] A Groupwise Association Test for Rare Mutations Using a Weighted Sum Statistic [J].

Madsen, Bo Eskerod ;

Browning, Sharon R. .

PLOS GENETICS, 2009, 5 (02)

[14] A common allele on chromosome 9 associated with coronary heart disease [J].

McPherson, Ruth ;

Pertsemlidis, Alexander ;

Kavaslar, Nihan ;

Stewart, Alexandre F. R. ;

Roberts, Robert ;

Cox, David R. ;

Hinds, David A. ;

Pennacchio, Len A. ;

Tybjaerg-Hansen, Anne ;

Folsom, Aaron R. ;

Boerwinkle, Eric ;

Hobbs, Helen H. ;

Cohen, Jonathan C. .

SCIENCE, 2007, 316 (5830) :1488-1491

[15] Genomewide association analysis of coronary artery disease [J].

Samani, Nilesh J. ;

Erdmann, Jeanette ;

Hall, Alistair S. ;

Hengstenberg, Christian ;

Mangino, Massimo ;

Mayer, Bjoern ;

Dixon, Richard J. ;

Meitinger, Thomas ;

Braund, Peter ;

Wichmann, H.-Erich ;

Barrett, Jennifer H. ;

Koenig, Inke R. ;

Stevens, Suzanne E. ;

Szymczak, Silke ;

Tregouet, David-Alexandre ;

Iles, Mark M. ;

Pahlke, Friedrich ;

Pollard, Helen ;

Lieb, Wolfgang ;

Cambien, Francois ;

Fischer, Marcus ;

Ouwehand, Willem ;

Blankenberg, Stefan ;

Balmforth, Anthony J. ;

Baessler, Andrea ;

Ball, Stephen G. ;

Strom, Tim M. ;

Braenne, Ingrid ;

Gieger, Christian ;

Deloukas, Panos ;

Tobin, Martin D. ;

Ziegler, Andreas ;

Thompson, John R. ;

Schunkert, Heribert .

NEW ENGLAND JOURNAL OF MEDICINE, 2007, 357 (05) :443-453

[16] Periostin is essential for cardiac healing after acute myocardial infarction [J].

Shimazaki, Masashi ;

Nakamura, Kazuto ;

Kii, Isao ;

Kashima, Takeshi ;

Amizuka, Norio ;

Li, Minqi ;

Saito, Mitsuru ;

Fukuda, Keiichi ;

Nishiyama, Takashi ;

Kitajima, Satoshi ;

Saga, Yumiko ;

Fukayama, Masashi ;

Sata, Masataka ;

Kudo, Akira .

JOURNAL OF EXPERIMENTAL MEDICINE, 2008, 205 (02) :295-303

[17] Prevalence and extent of atherosclerosis in adolescents and young adults - Implications for prevention from the pathobiological determinants of atherosclerosis in youth study [J].

Strong, JP ;

Malcom, GT ;

McMahan, CA ;

Tracy, RE ;

Newman, WP ;

Herderick, EE ;

Cornhill, JF .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1999, 281 (08) :727-735

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