4-Hexylresorcinol: pharmacologic chaperone and its application for wound healing

被引：12
作者：
Kim, Seong-Gon [1 ,2 ]
机构：
[1] Wonju Natl Univ, Coll Dent, Dept Oral & Maxillofacial Surg, Gangneung, Kangnung, Gangwondo, South Korea
[2] Gangneung Wonju Natl Univ, Coll Dent, Dept Oral & Maxillofacial Surg, Kangnung 28644, Gangwondo, South Korea
来源：
MAXILLOFACIAL PLASTIC AND RECONSTRUCTIVE SURGERY | 2022年 / 44卷 / 01期
关键词：
SACCHAROMYCES-CEREVISIAE; HDAC INHIBITORS; SUPPRESSION; SIRT1; RESPONSES; DISEASE; MACROPHAGES; RESVERATROL; ACTIVATION; INDUCTION;
D O I：
10.1186/s40902-022-00334-w
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
4-Hexylresorcinol (4HR) is amphiphilic organic chemical and auto-regulator for micro-organism. As 4HR administration induces the stress on the endoplasmic reticulum, 4HR changes protein folding. The application of 4HR inhibits NE-kappa B signal pathway and TNF-alpha production. In addition, 4HR administration increases VEGF, TGF-beta 1, and calcification associated proteins. As a consequence, 4HR administration increases angiogenesis and bone formation in wounded area. Strong anti-inflammatory reaction and capillary regeneration in diabetic model demonstrate that 4HR can be applied on many types of surgical wound.
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页数：10
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