Diagnosis of gestational diabetes mellitus by use of the homeostasis model assessment-insulin resistance index in the first trimester

被引：39

作者：

Ozcimen, Emel Ebru ^{[1
]}

Uckuyu, Ayla ^{[1
]}

Ciftci, Faika Ceylan ^{[1
]}

Yanik, Filiz Fatma ^{[1
]}

Bakar, Coskun ^{[2
]}

机构：

[1] Baskent Univ Hosp, Dept Obstet & Gynecol, Baskent, Turkey

[2] Baskent Univ Hosp, Dept Publ Hlth, Baskent, Turkey

来源：

GYNECOLOGICAL ENDOCRINOLOGY | 2008年 / 24卷 / 04期

关键词：

gestational diabetes mellitus; homeostasis model assessment insulin resistance index; insulin resistance;

D O I：

10.1080/09513590801948416

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective. Gestational diabetes mellitus (GDM) affects 2-10% of all pregnant women, causing increased morbidity and mortality, and is tested for in the second trimester of pregnancy. The purpose of the present study was to predict GDM in the first trimester. Design and methods. The study included 271 patients who were between the 10th and 14th week of gestation. Fasting glucose and insulin were measured in the first trimester and the homeostasis model assessment-insulin resistance index (HOMA-IR) was calculated for each patient. These values were compared with the results of the second-trimester glucose tolerance test. Results. HOMA-IR values were higher in women with GDM. A cut-off value of 2.60 for HOMA-IR was calculated at the end of the study. Conclusion. Accepting patients whose HOMA-IR value is higher than 2.60 in the first trimester seems to be a good method to predict GDM.

引用

页码：224 / 229

页数：6

共 25 条

[1]

American College of Obstetricians and Gynecologists Committee on Practice Bulletins--Obstetrics, 2001, Obstet Gynecol, V98, P525

[2]

[Anonymous], 2006, The IDF consensus worldwide definition of the metabolic syndrome

[3] QUANTITATIVE ESTIMATION OF INSULIN SENSITIVITY [J].

BERGMAN, RN ;

IDER, YZ ;

BOWDEN, CR ;

COBELLI, C .

AMERICAN JOURNAL OF PHYSIOLOGY, 1979, 236 (06) :E667-E677

[4] Prediction of gestational diabetes mellitus in a high-risk group by insulin measurement in early pregnancy [J].

Bitó, T ;

Földesi, I ;

Nyári, T ;

Pál, A .

DIABETIC MEDICINE, 2005, 22 (10) :1434-1439

[5] CRITERIA FOR SCREENING-TESTS FOR GESTATIONAL DIABETES [J].

CARPENTER, MW ;

COUSTAN, DR .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1982, 144 (07) :768-773

[6] Longitudinal changes in glucose metabolism during pregnancy in obese women with normal glucose tolerance and gestational diabetes mellitus [J].

Catalano, PM ;

Huston, L ;

Amini, SB ;

Kalhan, SC .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1999, 180 (04) :903-914

[7] Gestational diabetes: Should it be added to the syndrome of insulin resistance? [J].

Clark, CM ;

Qiu, CF ;

Amerman, B ;

Porter, B ;

Fineberg, N ;

Aldasouqi, S ;

Golichowski, A .

DIABETES CARE, 1997, 20 (05) :867-871

[8] Longitudinal assessment of insulin sensitivity in pregnancy. Validation of the homeostasis model assessment [J].

Cohen, Ohad ;

Epstein, Gil S. ;

Weisz, Boaz ;

Homko, Carol J. ;

Sivan, Eyal .

CLINICAL ENDOCRINOLOGY, 2006, 64 (06) :640-644

[9]

DEFRONZO RA, 1979, AM J PHYSIOL, V237, pE214

[10] Differences in insulin sensitivity in pregnant women with overweight and gestational diabetes mellitus [J].

Endo, Satoko ;

Maeda, Kazuhisa ;

Suto, Masanori ;

Kaji, Takashi ;

Morine, Mikio ;

Kinoshita, Toshiko ;

Yasui, Toshiyuki ;

Irahara, Minoru .

GYNECOLOGICAL ENDOCRINOLOGY, 2006, 22 (06) :343-349

← 1 2 3 →