Intact pap2 downstream of macr-1 appears to be required for colistin resistance

被引：14

作者：

Choi, Yujin ^{[1
]}

Lee, Ji-Young ^{[1
]}

Lim, Suk-Kyung ^{[2
]}

Ko, Kwan Soo ^{[1
]}

机构：

[1] Sungkyunkwan Univ, Dept Mol Cell Biol, Sch Med, Suwon 16419, South Korea

[2] Anim & Plant Quarantine Agcy, Bacterial Dis Div, Gimcheon 39660, South Korea

来源：

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2020年 / 97卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

Colistin resistance; mcr-1; pap2; LIVESTOCK; PLASMIDS;

D O I：

10.1016/j.diagmicrobio.2020.114997

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

In this study, we investigated the effect of pap2 on colistin susceptibility using intact pap2 and truncated pap2 (pap2 Delta 351) genes, which were found along with mcr-1 in plasmid. Our experiments based on conjugation, antibiotic susceptibility testing, and time-killing assay showed that an intact pap2 gene is necessary along with mcr-1 for reduced colistin susceptibility. (C) 2020 Elsevier Inc. All rights reserved.

引用

页数：4

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