Ghrelin induces growth hormone (GH) secretion via nitric oxide (NO)/cGMP signaling

被引：19

作者：

Rodríguez-Pacheco, F ^{[1
]}

Luque, RM ^{[1
]}

García-Navarro, S ^{[1
]}

Gracia-Navarro, F ^{[1
]}

Castaño, JP ^{[1
]}

Malagón, MM ^{[1
]}

机构：

[1] Univ Cordoba, Dept Cell Biol Physiol & Immunol, Cordoba 14014, Spain

来源：

TRENDS IN COMPARATIVE ENDOCRINOLOGY AND NEUROBIOLOGY | 2005年 / 1040卷

关键词：

ghrelin; GH secretion; NO; cGMP;

D O I：

10.1196/annals.1327.087

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ghrelin, a recently discovered 28-aa peptide, stimulates GH release through a mechanism involving PLC- and cAMP-related signaling pathways. Recently, nitric oxide (NO) and its mediator, cGMP, have been shown to be required for the response of somatotropes to various regulators (GHRH, somatostatin, leptin). Here, we explore the possible role of the NO synthase (NOS)/NO/guanylate cyclase (GC)/cGMP signaling pathway in ghrelin-induced GH release from cultured pig somatotropes using blockers or activators of this route.

引用

页码：452 / 453

页数：2

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