Ghrelin induces growth hormone (GH) secretion via nitric oxide (NO)/cGMP signaling

被引：19

作者：

Rodríguez-Pacheco, F ^{[1
]}

Luque, RM ^{[1
]}

García-Navarro, S ^{[1
]}

Gracia-Navarro, F ^{[1
]}

Castaño, JP ^{[1
]}

Malagón, MM ^{[1
]}

机构：

[1] Univ Cordoba, Dept Cell Biol Physiol & Immunol, Cordoba 14014, Spain

来源：

TRENDS IN COMPARATIVE ENDOCRINOLOGY AND NEUROBIOLOGY | 2005年 / 1040卷

关键词：

ghrelin; GH secretion; NO; cGMP;

D O I：

10.1196/annals.1327.087

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ghrelin, a recently discovered 28-aa peptide, stimulates GH release through a mechanism involving PLC- and cAMP-related signaling pathways. Recently, nitric oxide (NO) and its mediator, cGMP, have been shown to be required for the response of somatotropes to various regulators (GHRH, somatostatin, leptin). Here, we explore the possible role of the NO synthase (NOS)/NO/guanylate cyclase (GC)/cGMP signaling pathway in ghrelin-induced GH release from cultured pig somatotropes using blockers or activators of this route.

引用

页码：452 / 453

页数：2

共 50 条

[1] Ghrelin induces growth hormone secretion via a nitric oxide/cGMP signalling pathway
Rodriguez-Pacheco, F.
Luque, R. M.
Tena-Sempere, M.
Malagon, M. M.
Castano, J. P.
JOURNAL OF NEUROENDOCRINOLOGY, 2008, 20 (03) : 406 - 412
[2] The role of circulating ghrelin in growth hormone (GH) secretion in freely moving male rats
Okimura, Y
Ukai, K
Hosoda, H
Murata, M
Iguchi, G
Iida, K
Kaji, H
Kojima, M
Kangawa, K
Chihara, K
LIFE SCIENCES, 2003, 72 (22) : 2517 - 2524
[3] Ghrelin: Ghrelin as a Regulatory Peptide in Growth Hormone Secretion
Khatib, Nazli
Gaidhane, Shilpa
Gaidhane, Abhay M.
Khatib, Mahanaaz
Simkhada, Padam
Gode, Dilip
Quazi Syed, Zahiruddin
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2014, 8 (08) : MC13 - MC17
[4] Evidence that nitric oxide is involved in the regulation of growth hormone secretion in goldfish
Uretsky, AD
Chang, JP
GENERAL AND COMPARATIVE ENDOCRINOLOGY, 2000, 118 (03) : 461 - 470
[5] Modulation of growth hormone secretion through the action of growth hormone secretagogues and ghrelin
Lengyel, Ana-Maria J.
Paiva Cunha de Sa, Larissa Bianca
SALUD I CIENCIA, 2008, 16 (05): : 505 - 508
[6] Effects of ghrelin on growth hormone secretion in vivo in ruminants
Hashizume, T
Horiuchi, M
Nonaka, S
Kasuya, E
Kojima, M
Hosoda, H
Kangawa, K
REGULATORY PEPTIDES, 2005, 126 (1-2) : 61 - 65
[7] Ghrelin and growth hormone secretagogues (GHS): Modulation of growth hormone secretion and therapeutic applications
Correa-Silva, Sam R.
Paiva Cunha De Sa, Larissa Bianca
Lengyel, Ana-Maria J.
ARQUIVOS BRASILEIROS DE ENDOCRINOLOGIA E METABOLOGIA, 2008, 52 (05) : 726 - 733
[8] Growth hormone and ghrelin secretion are associated with clinical severity in Huntington's disease
Aziz, N. A.
Pijl, H.
Frolich, M.
Schroder-van der Elst, J. P.
van der Bent, C.
Roelfsema, F.
Roos, R. A. C.
EUROPEAN JOURNAL OF NEUROLOGY, 2010, 17 (02) : 280 - 288
[9] Ghrelin-induced growth hormone release from goldfish pituitary cells is nitric oxide dependent
Grey, Caleb L.
Chang, John P.
GENERAL AND COMPARATIVE ENDOCRINOLOGY, 2012, 179 (02) : 152 - 158
[10] Ghrelin stimulates proliferation of human osteoblastic TE85 cells via NO/cGMP signaling pathway
Deng-Hu Wang
Yun-Sheng Hu
Jun-Jie Du
Yun-Yu Hu
Wei-De Zhong
Wei-Jun Qin
Endocrine, 2009, 35 : 112 - 117

← 1 2 3 4 5 →