Genetic markers associated with cutaneous adverse drug reactions to allopurinol: aysystematic review

被引：4

作者：

Jarjour, Samantha ^{[1
]}

Barrette, Mathieu ^{[1
]}

Normand, Valerie ^{[2
]}

Rouleau, Jean Lucien ^{[3
,4
]}

Dube, Marie-Pierre ^{[2
,3
,4
]}

de Denus, Simon ^{[1
,2
,4
]}

机构：

[1] Univ Montreal, Fac Pharm, Montreal, PQ H3T 1J4, Canada

[2] Univ Montreal, Beaulieu Saucier Pharmacogen Ctr, Montreal, PQ, Canada

[3] Univ Montreal, Fac Med, Montreal, PQ, Canada

[4] Montreal Heart Inst, Res Ctr, Montreal, PQ H1T 1C8, Canada

来源：

PHARMACOGENOMICS | 2015年 / 16卷 / 07期

关键词：

adverse reaction; allopurinol; drug-induced hypersensitivity syndrome; HLA; pharmacogenomics; rash; safety; Stevens-Johnson syndrome; toxic epidermal necrolysis; STEVENS-JOHNSON-SYNDROME; TOXIC EPIDERMAL NECROLYSIS; HAN CHINESE; HLA-B; HLA-B-ASTERISK-5801; ALLELE; RISK; POPULATION; GUIDELINES; THERAPY;

D O I：

10.2217/PGS.15.21

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Pharmacogenomic markers in the HLA coding genes have been associated with drug hypersensitivity of multiple drugs, including allopurinol. In this systematic review, we summarize the pharmacogenomic evidence available regarding allopurinol-induced cutaneous adverse drug reactions (cADRs). We found that the HLA-B*5801 allele was significantly associated with the risk of severe cADRs in the Han Chinese, Korean, Thai, Japanese and European populations. The association between less severe cADRs and HLA-B*5801 was less consistent. All SNPs identified in genome-wide association studies of common variants were also located in or nearby HLA-B*5801. Future studies should focus on more common but less severe allopurinol-induced cADRs, as well as the potential role of rare variants as predictors of these cADRs.

引用

页码：755 / 767

页数：13

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