Characterizing Genetic Risk at Known Prostate Cancer Susceptibility Loci in African Americans

被引：101

作者：

Haiman, Christopher A. ^{[1
,2
]}

Chen, Gary K. ^{[1
,2
]}

Blot, William J. ^{[3
,4
,5
]}

Strom, Sara S. ^{[6
]}

Berndt, Sonja I. ^{[7
]}

Kittles, Rick A. ^{[8
]}

Rybicki, Benjamin A. ^{[9
]}

Isaacs, William B. ^{[10
,11
]}

Ingles, Sue A. ^{[1
,2
]}

Stanford, Janet L. ^{[12
]}

Diver, W. Ryan ^{[13
]}

Witte, John S. ^{[14
,15
]}

Chanock, Stephen J. ^{[7
]}

Kolb, Suzanne ^{[12
]}

Signorello, Lisa B. ^{[3
,4
,5
]}

Yamamura, Yuko ^{[6
]}

Neslund-Dudas, Christine ^{[9
]}

Thun, Michael J. ^{[13
]}

Murphy, Adam ^{[16
]}

Casey, Graham ^{[1
,2
]}

Sheng, Xin ^{[1
,2
]}

Wan, Peggy ^{[1
,2
]}

Pooler, Loreall C. ^{[1
,2
]}

Monroe, Kristine R. ^{[1
,2
]}

Waters, Kevin M. ^{[1
,2
]}

Le Marchand, Loic ^{[17
]}

Kolonel, Laurence N. ^{[17
]}

Stram, Daniel O. ^{[1
,2
]}

Henderson, Brian E. ^{[1
,2
]}

机构：

[1] Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA

[2] Univ So Calif, Norris Comprehens Canc Ctr, Los Angeles, CA 90033 USA

[3] Int Epidemiol Inst, Rockville, MD USA

[4] Vanderbilt Univ, Dept Med, Vanderbilt Epidemiol Ctr, Div Epidemiol, Nashville, TN USA

[5] Vanderbilt Ingram Canc Ctr, Nashville, TN USA

[6] Univ Texas MD Anderson Canc Ctr, Dept Epidemiol, Houston, TX 77030 USA

[7] NCI, NIH, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA

[8] Univ Illinois, Dept Med, Chicago, IL USA

[9] Henry Ford Hosp, Dept Biostat & Res Epidemiol, Detroit, MI 48202 USA

[10] Johns Hopkins Univ Hosp, James Buchanan Brady Urol Inst, Baltimore, MD 21287 USA

[11] Inst Med, Baltimore, MD 21287 USA

[12] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98104 USA

[13] Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA

[14] Univ Calif San Francisco, Inst Human Genet, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA

[15] Univ Calif San Francisco, Dept Urol, San Francisco, CA 94143 USA

[16] Northwestern Univ, Dept Urol, Chicago, IL 60611 USA

[17] Univ Hawaii, Canc Res Ctr, Program Epidemiol, Honolulu, HI 96813 USA

来源：

PLOS GENETICS | 2011年 / 7卷 / 05期

关键词：

GENOME-WIDE ASSOCIATION; SEQUENCE VARIANTS; MULTIPLE LOCI; 8Q24; COHORT; IDENTIFICATION;

D O I：

10.1371/journal.pgen.1001387

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

GWAS of prostate cancer have been remarkably successful in revealing common genetic variants and novel biological pathways that are linked with its etiology. A more complete understanding of inherited susceptibility to prostate cancer in the general population will come from continuing such discovery efforts and from testing known risk alleles in diverse racial and ethnic groups. In this large study of prostate cancer in African American men (3,425 prostate cancer cases and 3,290 controls), we tested 49 risk variants located in 28 genomic regions identified through GWAS in men of European and Asian descent, and we replicated associations (at p <= 0.05) with roughly half of these markers. Through fine-mapping, we identified nearby markers in many regions that better define associations in African Americans. At 8q24, we found 9 variants (p <= 6x10(-4)) that best capture risk of prostate cancer in African Americans, many of which are more common in men of African than European descent. The markers found to be associated with risk at each locus improved risk modeling in African Americans (per allele OR = 1.17) over the alleles reported in the original GWAS (OR = 1.08). In summary, in this detailed analysis of the prostate cancer risk loci reported from GWAS, we have validated and improved upon markers of risk in some regions that better define the association with prostate cancer in African Americans. Our findings with variants at 8q24 also reinforce the importance of this region as a major risk locus for prostate cancer in men of African ancestry.

引用

页数：11

共 45 条

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Agalliu, Ilir ;

Salinas, Claudia A. ;

Hansten, Philip D. ;

Ostrander, Elaine A. ;

Stanford, Janet L. .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 2008, 168 (03) :250-260

[2] Multiple loci on 8q24 associated with prostate cancer susceptibility [J].

Al Olama, Ali Amin ;

Kote-Jarai, Zsofia ;

Giles, Graham G. ;

Guy, Michelle ;

Morrison, Jonathan ;

Severi, Gianluca ;

Leongamornlert, Daniel A. ;

Tymrakiewicz, Malgorzata ;

Jhavar, Sameer ;

Saunders, Ed ;

Hopper, John L. ;

Southey, Melissa C. ;

Muir, Kenneth R. ;

English, Dallas R. ;

Dearnaley, David P. ;

Ardern-Jones, Audrey T. ;

Hall, Amanda L. ;

O'Brien, Lynne T. ;

Wilkinson, Rosemary A. ;

Sawyer, Emma ;

Lophatananon, Artitaya ;

Horwich, Alan ;

Huddart, Robert A. ;

Khoo, Vincent S. ;

Parker, Christopher C. ;

Woodhouse, Christopher J. ;

Thompson, Alan ;

Christmas, Tim ;

Ogden, Chris ;

Cooper, Colin ;

Donovan, Jenny L. ;

Hamdy, Freddie C. ;

Neal, David E. ;

Eeles, Rosalind A. ;

Easton, Douglas F. .

NATURE GENETICS, 2009, 41 (10) :1058-1060

[3] A common variant associated with prostate cancer in European and African populations [J].

Amundadottir, Laufey T. ;

Sulem, Patrick ;

Gudmundsson, Julius ;

Helgason, Agnar ;

Baker, Adam ;

Agnarsson, Bjarni A. ;

Sigurdsson, Asgeir ;

Benediktsdottir, Kristrun R. ;

Cazier, Jean-Baptiste ;

Sainz, Jesus ;

Jakobsdottir, Margret ;

Kostic, Jelena ;

Magnusdottir, Droplaug N. ;

Ghosh, Shyamali ;

Agnarsson, Kari ;

Birgisdottir, Birgitta ;

Le Roux, Louise ;

Olafsdottir, Adalheidur ;

Blondal, Thorarinn ;

Andresdottir, Margret ;

Gretarsdottir, Olafia Svandis ;

Bergthorsson, Jon T. ;

Gudbjartsson, Daniel ;

Gylfason, Arnaldur ;

Thorleifsson, Gudmar ;

Manolescu, Andrei ;

Kristjansson, Kristleifur ;

Geirsson, Gudmundur ;

Isaksson, Helgi ;

Douglas, Julie ;

Johansson, Jan-Erik ;

Balter, Katarina ;

Wiklund, Fredrik ;

Montie, James E. ;

Yu, Xiaoying ;

Suarez, Brian K. ;

Ober, Carole ;

Cooney, Kathleen A. ;

Gronberg, Henrik ;

Catalona, William J. ;

Einarsson, Gudmundur V. ;

Barkardottir, Rosa B. ;

Gulcher, Jeffrey R. ;

Kong, Augustine ;

Thorsteinsdottir, Unnur ;

Stefansson, Kari .

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[4] The American Cancer Society cancer prevention study II nutrition cohort - Rationale, study design, and baseline characteristics [J].

Calle, EE ;

Rodriguez, C ;

Jacobs, EJ ;

Almon, ML ;

Chao, A ;

McCullough, ML ;

Feigelson, HS ;

Thun, MJ .

CANCER, 2002, 94 (09) :2490-2501

[5]

Chang BL, 2010, CANC EPIDEMIOL BIOMA

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Crowther-Swanepoel, Dalemari ;

Broderick, Peter ;

Di Bernardo, Maria Chiara ;

Dobbins, Sara E. ;

Torres, Maria ;

Mansouri, Mahmoud ;

Ruiz-Ponte, Clara ;

Enjuanes, Anna ;

Rosenquist, Richard ;

Carracedo, Angel ;

Jurlander, Jesper ;

Campo, Elias ;

Juliusson, Gunnar ;

Montserrat, Emilio ;

Smedby, Karin E. ;

Dyer, Martin J. S. ;

Matutes, Estella ;

Dearden, Claire ;

Sunter, Nicola J. ;

Hall, Andrew G. ;

Mainou-Fowler, Tryfonia ;

Jackson, Graham H. ;

Summerfield, Geoffrey ;

Harris, Robert J. ;

Pettitt, Andrew R. ;

Allsup, David J. ;

Bailey, James R. ;

Pratt, Guy ;

Pepper, Chris ;

Fegan, Chris ;

Parker, Anton ;

Oscier, David ;

Allan, James M. ;

Catovsky, Daniel ;

Houlston, Richard S. .

NATURE GENETICS, 2010, 42 (02) :132-U59

[7] Genome-wide association study identifies novel breast cancer susceptibility loci [J].

Easton, Douglas F. ;

Pooley, Karen A. ;

Dunning, Alison M. ;

Pharoah, Paul D. P. ;

Thompson, Deborah ;

Ballinger, Dennis G. ;

Struewing, Jeffery P. ;

Morrison, Jonathan ;

Field, Helen ;

Luben, Robert ;

Wareham, Nicholas ;

Ahmed, Shahana ;

Healey, Catherine S. ;

Bowman, Richard ;

Meyer, Kerstin B. ;

Haiman, Christopher A. ;

Kolonel, Laurence K. ;

Henderson, Brian E. ;

Le Marchand, Loic ;

Brennan, Paul ;

Sangrajrang, Suleeporn ;

Gaborieau, Valerie ;

Odefrey, Fabrice ;

Shen, Chen-Yang ;

Wu, Pei-Ei ;

Wang, Hui-Chun ;

Eccles, Diana ;

Evans, D. Gareth ;

Peto, Julian ;

Fletcher, Olivia ;

Johnson, Nichola ;

Seal, Sheila ;

Stratton, Michael R. ;

Rahman, Nazneen ;

Chenevix-Trench, Georgia ;

Bojesen, Stig E. ;

Nordestgaard, Borge G. ;

Axelsson, Christen K. ;

Garcia-Closas, Montserrat ;

Brinton, Louise ;

Chanock, Stephen ;

Lissowska, Jolanta ;

Peplonska, Beata ;

Nevanlinna, Heli ;

Fagerholm, Rainer ;

Eerola, Hannaleena ;

Kang, Daehee ;

Yoo, Keun-Young ;

Noh, Dong-Young ;

Ahn, Sei-Hyun .

NATURE, 2007, 447 (7148) :1087-U7

[8] Multiple newly identified loci associated with prostate cancer susceptibility [J].

Eeles, Rosalind A. ;

Kote-Jarai, Zsofia ;

Giles, Graham G. ;

Al Olama, Ali Amin ;

Guy, Michelle ;

Jugurnauth, Sarah K. ;

Mulholland, Shani ;

Leongamornlert, Daniel A. ;

Edwards, Stephen M. ;

Morrison, Jonathan ;

Field, Helen I. ;

Southey, Melissa C. ;

Severi, Gianluca ;

Donovan, Jenny L. ;

Hamdy, Freddie C. ;

Dearnaley, David P. ;

Muir, Kenneth R. ;

Smith, Charmaine ;

Bagnato, Melisa ;

Ardern-Jones, Audrey T. ;

Hall, Amanda L. ;

O'Brien, Lynne T. ;

Gehr-Swain, Beatrice N. ;

Wilkinson, Rosemary A. ;

Cox, Angie ;

Lewis, Sarah ;

Brown, Paul M. ;

Jhavar, Sameer G. ;

Tymrakiewicz, Malgorzata ;

Lophatananon, Artitaya ;

Bryant, Sarah L. ;

Horwich, Alan ;

Huddart, Robert A. ;

Khoo, Vincent S. ;

Parker, Christopher C. ;

Woodhouse, Christopher J. ;

Thompson, Alan ;

Christmas, Tim ;

Ogden, Chris ;

Fisher, Cyril ;

Jamieson, Charles ;

Cooper, Colin S. ;

English, Dallas R. ;

Hopper, John L. ;

Neal, David E. ;

Easton, Douglas F. .

NATURE GENETICS, 2008, 40 (03) :316-321

[9] Identification of seven new prostate cancer susceptibility loci through a genome-wide association study [J].

Eeles, Rosalind A. ;

Kote-Jarai, Zsofia ;

Al Olama, Ali Amin ;

Giles, Graham G. ;

Guy, Michelle ;

Severi, Gianluca ;

Muir, Kenneth ;

Hopper, John L. ;

Henderson, Brian E. ;

Haiman, Christopher A. ;

Schleutker, Johanna ;

Hamdy, Freddie C. ;

Neal, David E. ;

Donovan, Jenny L. ;

Stanford, Janet L. ;

Ostrander, Elaine A. ;

Ingles, Sue A. ;

John, Esther M. ;

Thibodeau, Stephen N. ;

Schaid, Daniel ;

Park, Jong Y. ;

Spurdle, Amanda ;

Clements, Judith ;

Dickinson, Joanne L. ;

Maier, Christiane ;

Vogel, Walther ;

Doerk, Thilo ;

Rebbeck, Timothy R. ;

Cooney, Kathleen A. ;

Cannon-Albright, Lisa ;

Chappuis, Pierre O. ;

Hutter, Pierre ;

Zeegers, Maurice ;

Kaneva, Radka ;

Zhang, Hong-Wei ;

Lu, Yong-Jie ;

Foulkes, William D. ;

English, Dallas R. ;

Leongamornlert, Daniel A. ;

Tymrakiewicz, Malgorzata ;

Morrison, Jonathan ;

Ardern-Jones, Audrey T. ;

Hall, Amanda L. ;

O'Brien, Lynne T. ;

Wilkinson, Rosemary A. ;

Saunders, Edward J. ;

Page, Elizabeth C. ;

Sawyer, Emma J. ;

Edwards, Stephen M. ;

Dearnaley, David P. .

NATURE GENETICS, 2009, 41 (10) :1116-U97

[10] Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men [J].

Freedman, Matthew L. ;

Haiman, Christopher A. ;

Patterson, Nick ;

McDonald, Gavin J. ;

Tandon, Arti ;

Waliszewska, Alicja ;

Penney, Kathryn ;

Steen, Robert G. ;

Ardlie, Kristin ;

John, Esther M. ;

Clakley-Girvan, Ingrid ;

Whitternore, Alice S. ;

Cooney, Kathleen A. ;

Ingles, Sue A. ;

Altshuler, David ;

Henderson, Brian E. ;

Reich, David .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (38) :14068-14073

← 1 2 3 4 5 →

共 45 条

[1] Statin use and risk of prostate cancer: Results from a population-based epidemiologic study [J].

Agalliu, Ilir ;

Salinas, Claudia A. ;

Hansten, Philip D. ;

Ostrander, Elaine A. ;

Stanford, Janet L. .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 2008, 168 (03) :250-260

[2] Multiple loci on 8q24 associated with prostate cancer susceptibility [J].

Al Olama, Ali Amin ;

Kote-Jarai, Zsofia ;

Giles, Graham G. ;

Guy, Michelle ;

Morrison, Jonathan ;

Severi, Gianluca ;

Leongamornlert, Daniel A. ;

Tymrakiewicz, Malgorzata ;

Jhavar, Sameer ;

Saunders, Ed ;

Hopper, John L. ;

Southey, Melissa C. ;

Muir, Kenneth R. ;

English, Dallas R. ;

Dearnaley, David P. ;

Ardern-Jones, Audrey T. ;

Hall, Amanda L. ;

O'Brien, Lynne T. ;

Wilkinson, Rosemary A. ;

Sawyer, Emma ;

Lophatananon, Artitaya ;

Horwich, Alan ;

Huddart, Robert A. ;

Khoo, Vincent S. ;

Parker, Christopher C. ;

Woodhouse, Christopher J. ;

Thompson, Alan ;

Christmas, Tim ;

Ogden, Chris ;

Cooper, Colin ;

Donovan, Jenny L. ;

Hamdy, Freddie C. ;

Neal, David E. ;

Eeles, Rosalind A. ;

Easton, Douglas F. .

NATURE GENETICS, 2009, 41 (10) :1058-1060

[3] A common variant associated with prostate cancer in European and African populations [J].

Amundadottir, Laufey T. ;

Sulem, Patrick ;

Gudmundsson, Julius ;

Helgason, Agnar ;

Baker, Adam ;

Agnarsson, Bjarni A. ;

Sigurdsson, Asgeir ;

Benediktsdottir, Kristrun R. ;

Cazier, Jean-Baptiste ;

Sainz, Jesus ;

Jakobsdottir, Margret ;

Kostic, Jelena ;

Magnusdottir, Droplaug N. ;

Ghosh, Shyamali ;

Agnarsson, Kari ;

Birgisdottir, Birgitta ;

Le Roux, Louise ;

Olafsdottir, Adalheidur ;

Blondal, Thorarinn ;

Andresdottir, Margret ;

Gretarsdottir, Olafia Svandis ;

Bergthorsson, Jon T. ;

Gudbjartsson, Daniel ;

Gylfason, Arnaldur ;

Thorleifsson, Gudmar ;

Manolescu, Andrei ;

Kristjansson, Kristleifur ;

Geirsson, Gudmundur ;

Isaksson, Helgi ;

Douglas, Julie ;

Johansson, Jan-Erik ;

Balter, Katarina ;

Wiklund, Fredrik ;

Montie, James E. ;

Yu, Xiaoying ;

Suarez, Brian K. ;

Ober, Carole ;

Cooney, Kathleen A. ;

Gronberg, Henrik ;

Catalona, William J. ;

Einarsson, Gudmundur V. ;

Barkardottir, Rosa B. ;

Gulcher, Jeffrey R. ;

Kong, Augustine ;

Thorsteinsdottir, Unnur ;

Stefansson, Kari .

NATURE GENETICS, 2006, 38 (06) :652-658

[4] The American Cancer Society cancer prevention study II nutrition cohort - Rationale, study design, and baseline characteristics [J].

Calle, EE ;

Rodriguez, C ;

Jacobs, EJ ;

Almon, ML ;

Chao, A ;

McCullough, ML ;

Feigelson, HS ;

Thun, MJ .

CANCER, 2002, 94 (09) :2490-2501

[5]

Chang BL, 2010, CANC EPIDEMIOL BIOMA

[6] Common variants at 2q37.3, 8q24.21, 15q21.3 and 16q24.1 influence chronic lymphocytic leukemia risk [J].

Crowther-Swanepoel, Dalemari ;

Broderick, Peter ;

Di Bernardo, Maria Chiara ;

Dobbins, Sara E. ;

Torres, Maria ;

Mansouri, Mahmoud ;

Ruiz-Ponte, Clara ;

Enjuanes, Anna ;

Rosenquist, Richard ;

Carracedo, Angel ;

Jurlander, Jesper ;

Campo, Elias ;

Juliusson, Gunnar ;

Montserrat, Emilio ;

Smedby, Karin E. ;

Dyer, Martin J. S. ;

Matutes, Estella ;

Dearden, Claire ;

Sunter, Nicola J. ;

Hall, Andrew G. ;

Mainou-Fowler, Tryfonia ;

Jackson, Graham H. ;

Summerfield, Geoffrey ;

Harris, Robert J. ;

Pettitt, Andrew R. ;

Allsup, David J. ;

Bailey, James R. ;

Pratt, Guy ;

Pepper, Chris ;

Fegan, Chris ;

Parker, Anton ;

Oscier, David ;

Allan, James M. ;

Catovsky, Daniel ;

Houlston, Richard S. .

NATURE GENETICS, 2010, 42 (02) :132-U59

[7] Genome-wide association study identifies novel breast cancer susceptibility loci [J].

Easton, Douglas F. ;

Pooley, Karen A. ;

Dunning, Alison M. ;

Pharoah, Paul D. P. ;

Thompson, Deborah ;

Ballinger, Dennis G. ;

Struewing, Jeffery P. ;

Morrison, Jonathan ;

Field, Helen ;

Luben, Robert ;

Wareham, Nicholas ;

Ahmed, Shahana ;

Healey, Catherine S. ;

Bowman, Richard ;

Meyer, Kerstin B. ;

Haiman, Christopher A. ;

Kolonel, Laurence K. ;

Henderson, Brian E. ;

Le Marchand, Loic ;

Brennan, Paul ;

Sangrajrang, Suleeporn ;

Gaborieau, Valerie ;

Odefrey, Fabrice ;

Shen, Chen-Yang ;

Wu, Pei-Ei ;

Wang, Hui-Chun ;

Eccles, Diana ;

Evans, D. Gareth ;

Peto, Julian ;

Fletcher, Olivia ;

Johnson, Nichola ;

Seal, Sheila ;

Stratton, Michael R. ;

Rahman, Nazneen ;

Chenevix-Trench, Georgia ;

Bojesen, Stig E. ;

Nordestgaard, Borge G. ;

Axelsson, Christen K. ;

Garcia-Closas, Montserrat ;

Brinton, Louise ;

Chanock, Stephen ;

Lissowska, Jolanta ;

Peplonska, Beata ;

Nevanlinna, Heli ;

Fagerholm, Rainer ;

Eerola, Hannaleena ;

Kang, Daehee ;

Yoo, Keun-Young ;

Noh, Dong-Young ;

Ahn, Sei-Hyun .

NATURE, 2007, 447 (7148) :1087-U7

[8] Multiple newly identified loci associated with prostate cancer susceptibility [J].

Eeles, Rosalind A. ;

Kote-Jarai, Zsofia ;

Giles, Graham G. ;

Al Olama, Ali Amin ;

Guy, Michelle ;

Jugurnauth, Sarah K. ;

Mulholland, Shani ;

Leongamornlert, Daniel A. ;

Edwards, Stephen M. ;

Morrison, Jonathan ;

Field, Helen I. ;

Southey, Melissa C. ;

Severi, Gianluca ;

Donovan, Jenny L. ;

Hamdy, Freddie C. ;

Dearnaley, David P. ;

Muir, Kenneth R. ;

Smith, Charmaine ;

Bagnato, Melisa ;

Ardern-Jones, Audrey T. ;

Hall, Amanda L. ;

O'Brien, Lynne T. ;

Gehr-Swain, Beatrice N. ;

Wilkinson, Rosemary A. ;

Cox, Angie ;

Lewis, Sarah ;

Brown, Paul M. ;

Jhavar, Sameer G. ;

Tymrakiewicz, Malgorzata ;

Lophatananon, Artitaya ;

Bryant, Sarah L. ;

Horwich, Alan ;

Huddart, Robert A. ;

Khoo, Vincent S. ;

Parker, Christopher C. ;

Woodhouse, Christopher J. ;

Thompson, Alan ;

Christmas, Tim ;

Ogden, Chris ;

Fisher, Cyril ;

Jamieson, Charles ;

Cooper, Colin S. ;

English, Dallas R. ;

Hopper, John L. ;

Neal, David E. ;

Easton, Douglas F. .

NATURE GENETICS, 2008, 40 (03) :316-321

[9] Identification of seven new prostate cancer susceptibility loci through a genome-wide association study [J].

Eeles, Rosalind A. ;

Kote-Jarai, Zsofia ;

Al Olama, Ali Amin ;

Giles, Graham G. ;

Guy, Michelle ;

Severi, Gianluca ;

Muir, Kenneth ;

Hopper, John L. ;

Henderson, Brian E. ;

Haiman, Christopher A. ;

Schleutker, Johanna ;

Hamdy, Freddie C. ;

Neal, David E. ;

Donovan, Jenny L. ;

Stanford, Janet L. ;

Ostrander, Elaine A. ;

Ingles, Sue A. ;

John, Esther M. ;

Thibodeau, Stephen N. ;

Schaid, Daniel ;

Park, Jong Y. ;

Spurdle, Amanda ;

Clements, Judith ;

Dickinson, Joanne L. ;

Maier, Christiane ;

Vogel, Walther ;

Doerk, Thilo ;

Rebbeck, Timothy R. ;

Cooney, Kathleen A. ;

Cannon-Albright, Lisa ;

Chappuis, Pierre O. ;

Hutter, Pierre ;

Zeegers, Maurice ;

Kaneva, Radka ;

Zhang, Hong-Wei ;

Lu, Yong-Jie ;

Foulkes, William D. ;

English, Dallas R. ;

Leongamornlert, Daniel A. ;

Tymrakiewicz, Malgorzata ;

Morrison, Jonathan ;

Ardern-Jones, Audrey T. ;

Hall, Amanda L. ;

O'Brien, Lynne T. ;

Wilkinson, Rosemary A. ;

Saunders, Edward J. ;

Page, Elizabeth C. ;

Sawyer, Emma J. ;

Edwards, Stephen M. ;

Dearnaley, David P. .

NATURE GENETICS, 2009, 41 (10) :1116-U97

[10] Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men [J].

Freedman, Matthew L. ;

Haiman, Christopher A. ;

Patterson, Nick ;

McDonald, Gavin J. ;

Tandon, Arti ;

Waliszewska, Alicja ;

Penney, Kathryn ;

Steen, Robert G. ;

Ardlie, Kristin ;

John, Esther M. ;

Clakley-Girvan, Ingrid ;

Whitternore, Alice S. ;

Cooney, Kathleen A. ;

Ingles, Sue A. ;

Altshuler, David ;

Henderson, Brian E. ;

Reich, David .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (38) :14068-14073

← 1 2 3 4 5 →