Asymmetric Mukaiyama Aldol Reaction Catalyzed by C2-Symmetric N,N′-Dioxide-Ni(II) Complex

被引：10

作者：

Zhao, Jiannan ^{[1
]}

Zheng, Ke ^{[1
]}

Yang, Yang ^{[1
]}

Shi, Jian ^{[1
]}

Lin, Lili ^{[1
]}

Liu, Xiaohua ^{[1
]}

Feng, Xiaoming ^{[1
]}

机构：

[1] Sichuan Univ, Coll Chem, Minist Educ, Key Lab Green Chem & Technol, Chengdu 610064, Peoples R China

来源：

SYNLETT | 2011年 / 07期

基金：

中国国家自然科学基金;

关键词：

asymmetric catalysis; N; N '-dioxides complex; nickel; Mukaiyama aldol reaction; glyoxal derivatives; CHIRAL LEWIS-ACIDS; C(2)-SYMMETRIC COPPER(II) COMPLEXES; HYDROGEN-BOND CATALYSIS; KETENE SILYL ACETALS; ENANTIOSELECTIVE SYNTHESIS; GLYOXYLATE ESTERS; ALPHA-KETOESTERS; PYRUVATE ESTERS; DIELS-ALDER; ADDITIONS;

D O I：

10.1055/s-0030-1259698

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The N,N'-dioxide-Ni(II) complex has been developed for the asymmetric Mukaiyama aldol reaction between glyoxal derivatives and enolsilane which produced the 2-hydroxy-1,4-dicarbonyl compounds in moderate to high yields (up to 95%) with excellent enantioselectivities (up to 95% ee). Based on the configuration of the product and X-ray structure of the catalyst, a possible transition state was proposed to explain the mechanism of the reaction.

引用

页码：903 / 906

页数：4

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