Sesn2/AMPK/mTOR signaling mediates balance between survival and apoptosis in sensory hair cells under stress

被引：29
作者：
Bodmer, Daniel [1 ]
Levano-Huaman, Soledad [1 ,2 ]
机构：
[1] Univ Basel Hosp, Dept Biomed, Hebelstr 20, CH-4031 Basel, Switzerland
[2] Univ Basel Hosp, Dept Otolaryngol Head & Neck Surg, Petersgraben 4, CH-4031 Basel, Switzerland
来源：
CELL DEATH & DISEASE | 2017年 / 8卷
关键词：
INDUCED HEARING-LOSS; SESTRIN2; ACTIVATION; AUTOPHAGY; NRF2;
D O I：
10.1038/cddis.2017.457
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
引用
收藏
页码：e3068 / e3068
页数：3
相关论文
共 14 条
[1]   Direct detection of ototoxicant-induced reactive oxygen species generation in cochlear explants [J].
Clerici, WJ ;
Hensley, K ;
DiMartino, DL ;
Butterfield, DA .
HEARING RESEARCH, 1996, 98 (1-2) :116-124
[2]   Sesn2 gene ablation enhances susceptibility to gentamicin-induced hair cell death via modulation of AMPK/mTOR signaling [J].
Ebnoether, Eliane ;
Ramseier, Alessia ;
Cortada, Maurizio ;
Bodmer, Daniel ;
Levano-Huaman, Soledad .
CELL DEATH DISCOVERY, 2017, 3
[3]   Protective role of Nrf2 in age-related hearing loss and gentamicin ototoxicity [J].
Hoshino, Tomofumi ;
Tabuchi, Keiji ;
Nishimura, Bungo ;
Tanaka, Shuho ;
Nakayama, Masahiro ;
Ishii, Tetsuro ;
Warabi, Eiji ;
Yanagawa, Toru ;
Shimizu, Ritsuku ;
Yamamoto, Masayuki ;
Hara, Akira .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2011, 415 (01) :94-98
[4]   Antioxidant Activity of Sestrin 2 Controls Neuropathic Pain After Peripheral Nerve Injury [J].
Kallenborn-Gerhardt, Wiebke ;
Lu, Ruirui ;
Syhr, Katharina M. J. ;
Heidler, Juliana ;
von Melchner, Harald ;
Geisslinger, Gerd ;
Bangsow, Thorsten ;
Schmidtko, Achim .
ANTIOXIDANTS & REDOX SIGNALING, 2013, 19 (17) :2013-2023
[5]   Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains [J].
Kim, Hanseong ;
An, Sojin ;
Ro, Seung-Hyun ;
Teixeira, Filipa ;
Park, Gyeong Jin ;
Kim, Cheal ;
Cho, Chun-Seok ;
Kim, Jeong-Sig ;
Jakob, Ursula ;
Lee, Jun Hee ;
Cho, Uhn-Soo .
NATURE COMMUNICATIONS, 2015, 6
[6]   Maintenance of Metabolic Homeostasis by Sestrin2 and Sestrin3 [J].
Lee, Jun Hee ;
Budanov, Andrei V. ;
Talukdar, Saswata ;
Park, Eek Joong ;
Park, Hae Li ;
Park, Hwan-Woo ;
Bandyopadhyay, Gautam ;
Li, Ning ;
Aghajan, Mariam ;
Jang, Insook ;
Wolfe, Amber M. ;
Perkins, Guy A. ;
Ellisman, Mark H. ;
Bier, Ethan ;
Scadeng, Miriam ;
Foretz, Marc ;
Viollet, Benoit ;
Olefsky, Jerrold ;
Karin, Michael .
CELL METABOLISM, 2012, 16 (03) :311-321
[7]   Sestrin as a Feedback Inhibitor of TOR That Prevents Age-Related Pathologies [J].
Lee, Jun Hee ;
Budanov, Andrei V. ;
Park, Eek Joong ;
Birse, Ryan ;
Kim, Teddy E. ;
Perkins, Guy A. ;
Ocorr, Karen ;
Ellisman, Mark H. ;
Bodmer, Rolf ;
Bier, Ethan ;
Karin, Michael .
SCIENCE, 2010, 327 (5970) :1223-1228
[8]   Stimulation of autophagy by the p53 target gene Sestrin2 [J].
Maiuri, Maria Chiara ;
Malik, Shoaib Ahmad ;
Morselli, Eugenia ;
Kepp, Oliver ;
Criollo, Alfredo ;
Mouchel, Pierre-Luc ;
Carnuccio, Rosa ;
Kroemer, Guido .
CELL CYCLE, 2009, 8 (10) :1571-1576
[9]   Sestrin2 promotes LKB1-mediated AMPK activation in the ischemic heart [J].
Morrison, Alex ;
Chen, Li ;
Wang, Jinli ;
Zhang, Ming ;
Yang, Hui ;
Ma, Yina ;
Budanov, Andrei ;
Lee, Jun Hee ;
Karin, Michael ;
Li, Ji .
FASEB JOURNAL, 2015, 29 (02) :408-417
[10]   Acoustic overstimulation activates 5′-AMP-activated protein kinase through a temporary decrease in ATP level in the cochlear spiral ligament prior to permanent hearing loss in mice [J].
Nagashima, Reiko ;
Yamaguchi, Taro ;
Kuramoto, Nobuyuki ;
Ogita, Kiyokazu .
NEUROCHEMISTRY INTERNATIONAL, 2011, 59 (06) :812-820
12