Hyaluronic Acid Hydrogels for Biomedical Applications

被引:1630
作者
Burdick, Jason A. [1 ]
Prestwich, Glenn D. [2 ,3 ]
机构
[1] Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USA
[2] Univ Utah, Dept Med Chem, Salt Lake City, UT 84108 USA
[3] Univ Utah, Ctr Therapeut Biomat, Salt Lake City, UT 84108 USA
基金
美国国家卫生研究院; 美国国家科学基金会;
关键词
MESENCHYMAL STEM-CELLS; SYNTHETIC EXTRACELLULAR MATRICES; CROSS-LINKED HYDROGELS; IN-SITU; PHOTOCROSSLINKABLE HYALURONAN; NEOCARTILAGE FORMATION; BIOACTIVE HYDROGELS; CONTROLLED-RELEASE; GELATIN HYDROGELS; DIMENSIONS;
D O I
10.1002/adma.201003963
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Hyaluronic acid (HA), an immunoneutral polysaccharide that is ubiquitous in the human body, is crucial for many cellular and tissue functions and has been in clinical use for over thirty years. When chemically modified, HA can be transformed into many physical forms-viscoelastic solutions, soft or stiff hydrogels, electrospun fibers, non-woven meshes, macroporous and fibrillar sponges, flexible sheets, and nanoparticulate fluids-for use in a range of preclinical and clinical settings. Many of these forms are derived from the chemical crosslinking of pendant reactive groups by addition/condensation chemistry or by radical polymerization. Clinical products for cell therapy and regenerative medicine require crosslinking chemistry that is compatible with the encapsulation of cells and injection into tissues. Moreover, an injectable clinical biomaterial must meet marketing, regulatory, and financial constraints to provide affordable products that can be approved, deployed to the clinic, and used by physicians. Many HA-derived hydrogels meet these criteria, and can deliver cells and therapeutic agents for tissue repair and regeneration. This progress report covers both basic concepts and recent advances in the development of HA-based hydrogels for biomedical applications.
引用
收藏
页码:H41 / H56
页数:16
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