Characteristics of extracellular cyclic AMP-dependent protein kinase as a biomarker of cancer in dogs

被引：6
作者：
Bhang, D. H. [1 ]
Choi, U. S. [2 ,3 ]
Kim, B. G. [1 ]
Lee, S-N [1 ]
Lee, S. [1 ]
Roh, H-S [1 ]
Chung, W-J [4 ]
Jeon, K. O. [5 ]
Song, W. J. [5 ]
Youn, H-Y. [5 ]
Baek, K-H. [1 ]
机构：
[1] Sungkyunkwan Univ, Samsung Biomed Res Inst, Dept Mol & Cellular Biol, Sch Med, Suwon 440746, Gyeonggi, South Korea
[2] Chonbuk Natl Univ, Dept Vet Clin Pathol, Coll Vet Med, Jeonju, South Korea
[3] Chonbuk Natl Univ, Biosafety Res Inst, Coll Vet Med, Jeonju, South Korea
[4] Ray Vet Med Ctr, Seoul, South Korea
[5] Seoul Natl Univ, Dept Vet Internal Med, Coll Vet Med, Plus Program Vet Sci BK21, Seoul 151742, South Korea
来源：
VETERINARY AND COMPARATIVE ONCOLOGY | 2017年 / 15卷 / 04期
基金：
新加坡国家研究基金会;
关键词：
cancer biomarker; dog; enzyme-linked immunosorbent assay; extracellular protein kinase A; serum; C-REACTIVE PROTEIN; REGULATORY SUBUNIT; ALPHA(1)-ACID GLYCOPROTEIN; ALPHA-1-ACID GLYCOPROTEIN; MULTICENTRIC LYMPHOMA; MAMMARY-TUMORS; SERUM; EXPRESSION; ALPHA; OVEREXPRESSION;
D O I：
10.1111/vco.12304
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
Objective: Early and proper diagnosis of cancer is the most critical factor for the survival and treatment of veterinary cancer patients. In this study, we evaluated extracellular cyclic AMP-dependent protein kinase A (ECPKA) level in serum as a useful cancer biomarker in dogs. Methods: ECPKA levels were detected in sera from dogs with cancers (n=48), benign tumours (n=18), and non-tumour diseases (n=102) as well as healthy control dogs (n=54) utilizing enzyme-linked immunosorbent assay (ELISA). Results: Sera from dogs bearing various types of cancer exhibited markedly increased levels of ECPKA by up to 7.1-, 8.8-, and 10.9-fold compared with those from dogs harbouring benign tumours, dogs with non-tumour diseases, and healthy control dogs, respectively (P<.0001). In addition, serum ECPKA level did not show statistically significant correlation with gender, breed, or age of dogs or their non-cancerous disease conditions. Conclusion: Our data strongly propose that detection of serum ECPKA level is a potential and specific diagnostic tool for cancer in dogs.
引用
收藏
页码：1585 / 1589
页数：5
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