Natural and synthetic drugs used for the treatment of the dementia

被引：40

作者：

Dembitsky, Valery M. ^{[1
]}

Dzhemileva, Lilya ^{[2
]}

Gloriozova, Tatyana ^{[3
]}

D'yakonov, Vladimir ^{[2
]}

机构：

[1] Lethbridge Coll, Ctr Appl Res Innovat & Entrepreneurship, 3000 Coll Dr South, Lethbridge, AB T1K 1L6, Canada

[2] Russian Acad Sci, Inst Petrochem & Catalysis, Ufa 450075, Russia

[3] Russian Acad Sci, Inst Biomed Chem, Moscow 119121, Russia

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2020年 / 524卷 / 03期

关键词：

Dementia; Alzheimer's disease; Parkinson's disease; Huntington's disease; Myasthenia gravis; Memantine; Tacrine; Velnacrine; Rivastigmine; Donepezil; CYCLOARTANE-TYPE TRITERPENES; ALZHEIMERS-DISEASE; URSOLIC ACID; ACETYLCHOLINESTERASE INHIBITORS; SALVIA-MILTIORRHIZA; DAMMARANE TRITERPENES; STEROIDAL ALKALOIDS; PARKINSONS-DISEASE; SIGNALING PATHWAY; MEDICINAL-PLANTS;

D O I：

10.1016/j.bbrc.2020.01.123

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review is devoted to comparative pharmacological analysis of synthetic drugs such as memantine and its isomers, as well as tacrine, velnacrine, rivastigmine, and donepezil, with natural alkaloids, terpenoids, and triterpenoid peroxides, which are used to treat dementia, Alzheimer's and Parkinson's diseases, myasthenia gravis and other neurodegenerative diseases. Recently discovered by French scientists from Marseille triterpenoid hydroperoxides demonstrate high activity as potential therapeutic agents for the treatment of dementia. The information presented in this review is of great interest to pharmacologists, medical chemists, physiologists, neurologists and doctors, as well as for the pharmaceutical industry. Crown Copyright (C) 2020 Published by Elsevier Inc. All rights reserved.

引用

页码：772 / 783

页数：12

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