Integrative Radiogenomics Approach for Risk Assessment of Postoperative and Adjuvant Chemotherapy Benefits for Gastric Cancer Patients

被引:8
|
作者
Jin, Yin [1 ]
Xu, Yilun [1 ]
Li, Yanyan [2 ,3 ]
Chen, Renpin [1 ]
Cai, Weiyang [1 ]
机构
[1] Wenzhou Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Wenzhou, Peoples R China
[2] Wenzhou Med Univ, Affiliated Hosp 2, Dept Urol, Wenzhou, Peoples R China
[3] Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou, Peoples R China
来源
FRONTIERS IN ONCOLOGY | 2021年 / 11卷
关键词
radiogenomics; adjuvant chemotherapy benefit; postoperative gastric cancer; nomogram; survival prediction; GENE-EXPRESSION; CHEMORADIOTHERAPY; SURVIVAL; DICOM;
D O I
10.3389/fonc.2021.755271
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Gastric cancer (GC) is a typical heterogeneous malignant tumor, whose insensitivity to chemotherapy is a common cause of tumor recurrence and metastasis. There is no doubt regarding the effectiveness of adjuvant chemotherapy (ACT) for GC, but the population for whom it is indicated and the selection of specific options remain the focus of present research. The conventional pathological TNM prediction focuses on cancer cells to predict prognosis, while they do not provide sufficient prediction. Enhanced computed tomography (CT) scanning is a validated tool that assesses the involvement of careful identification of the tumor, lymph node involvement, and metastatic spread. Using the radiomics approach, we selected the least absolute shrinkage and selection operator (LASSO) Cox regression model to build a radiomics signature for predicting the overall survival (OS) and disease-free survival (DFS) of patients with complete postoperative gastric cancer and further identifying candidate benefits from ACT. The radiomics trait-associated genes captured clinically relevant molecular pathways and potential chemotherapeutic drug metabolism mechanisms. Our results of precise surrogates using radiogenomics can lead to additional benefit from adjuvant chemotherapy and then survival prediction in postoperative GC patients.
引用
收藏
页数:11
相关论文
共 50 条
  • [31] The effect of early adjuvant chemotherapy on survival in patients with gastric cancer
    Markets, R.
    Brasiuniene, B.
    Grizas, S.
    Maleckas, A.
    Padvelskiene, I
    Endzinas, Z.
    ANNALS OF ONCOLOGY, 2007, 18 : VII55 - VII55
  • [32] TBX2 Expression predicts Tumor Recurrence and Adjuvant Chemotherapy Benefits in Gastric Cancer Patients following R0 Resection: a proposed approach for risk stratification
    Lu, Jun
    Xu, Yu
    Wang, Yao-hui
    Huang, Xiao-yan
    Wu, Yuan
    Xie, Jian-wei
    Wang, Jia-bin
    Lin, Jian-xian
    Li, Ping
    Zheng, Chao-hui
    Huang, Ai-min
    Huang, Chang-ming
    JOURNAL OF CANCER, 2020, 11 (11): : 3172 - 3179
  • [33] Comparison of neoadjuvant chemotherapy and postoperative adjuvant chemotherapy in the treatment of Borrmann type IV gastric cancer.
    Huang, Xingmao
    Yu Pengfei
    Fang, Jingquan
    Cao, Yang
    Ye, Zeyao
    Chai, Tengjiao
    Du, Yian
    Cheng, Xiangdong
    JOURNAL OF CLINICAL ONCOLOGY, 2022, 40 (16) : E16064 - E16064
  • [34] Updated Adjuvant Chemotherapy for Gastric Cancer
    Takayama, Toshizo
    Tsuji, Yasushi
    JOURNAL OF CLINICAL MEDICINE, 2023, 12 (21)
  • [35] ADJUVANT CHEMOTHERAPY IN GASTRIC-CANCER
    SCHLAG, P
    WORLD JOURNAL OF SURGERY, 1987, 11 (04) : 473 - 477
  • [37] Adjuvant chemotherapy for gastric cancer or not: A dilemma?
    Wu, Aiwen
    Ji, Jiafu
    JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2008, 100 (06): : 376 - 377
  • [38] Is there an indication for adjuvant chemotherapy in gastric cancer?
    Südhoff, T
    Schmiegel, W
    DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT, 2003, 128 : S110 - S112
  • [39] Neoadjuvant plus adjuvant chemotherapy benefits overall survival of locally advanced gastric cancer
    Chen, Xin-Zu
    Yang, Kun
    Liu, Jie
    Chen, Xiao-Long
    Hu, Jian-Kun
    WORLD JOURNAL OF GASTROENTEROLOGY, 2011, 17 (40) : 4542 - 4544
  • [40] Post-esophagectomy Adjuvant Chemotherapy Benefits Esophageal Cancer Patients
    Sohda, Makoto
    Saito, Hideyuki
    Kuriyama, Kengo
    Yoshida, Tomonori
    Kumakura, Yuji
    Honjyo, Hiroaki
    Hara, Keigo
    Ozawa, Daigo
    Suzuki, Shigemasa
    Tanaka, Naritaka
    Sakai, Makoto
    Miyazaki, Tatsuya
    Fukuchi, Minoru
    Kuwano, Hiroyuki
    IN VIVO, 2019, 33 (02): : 501 - 506